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Ruthenium-Catalyzed Cycloaddition of Benzocyclobutenones with Diols
Ruthenium-Catalyzed Insertion of Adjacent Diol Carbon Atoms into C–C Bonds: Entry to Type II Polyketides.
19 October 2017 (online)
The authors have reported intermolecular cycloadditions through formal insertion of saturated C–H bonds into C–C σ-bonds. A ruthenium(0)/dppp complex catalyzed the diastereoselective coupling reactions of benzocyclobutenones to adjacent saturated carbon centers in diols.
The cycloaddition via ruthenacycles from the benzocyclobutenones and dehydrogenation of the alcohols provides a convergent method for the construction of type II polyketide substructures.