Synfacts 2018; 14(07): 0761
DOI: 10.1055/s-0037-1610064
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Continuous-Flow Pd/C-Catalyzed Reductive Alkylation of Alcohols with Aldehydes

Yasuhiro Uozumi
Guanshuo Shen
Bruniaux S. Luart D. Len C. * Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, Compiègne, and PSL Research University, Paris, France
Continuous-Flow Reductive Alkylation: Synthesis of Bio-Based Symmetrical and Dissymmetrical Ethers.

Synthesis 2018;
50: 1849-1856
Further Information

Publication History

Publication Date:
18 June 2018 (online)



The authors have developed a continuous-flow system for the reductive alkylation of alcohols with aldehydes catalyzed by Pd/C in the presence of hydrogen, giving the corresponding ethers in 35–93% yield.



In the long-term flow reaction of butan-1-ol with octanal, butyl octyl ether was obtained in 50% yield after eight hours.