Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2019; 15(02): 0149
DOI: 10.1055/s-0037-1611985
DOI: 10.1055/s-0037-1611985
Metals in Synthesis
Enantioselective α-Functionalization of Ketones
He Z.-T,
Hartwig JF.
* University of California, Berkeley, USA
Enantioselective α-Functionalizations of Ketones via Allylic Substitution of Silyl Enol Ethers.
Nat. Chem. 2018;
DOI: 10.1038/s41557-018-0165-x.
Enantioselective α-Functionalizations of Ketones via Allylic Substitution of Silyl Enol Ethers.
Nat. Chem. 2018;
DOI: 10.1038/s41557-018-0165-x.
Further Information
Publication History
Publication Date:
18 January 2019 (online)
Significance
Hartwig and He developed an efficient and enantioselective method for the α-functionalization of ketones by performing iridium-catalyzed allylic substitutions on silyl enol ethers.
#
Comment
The yields and enantio- or diastereoselectivities of this method are exceptionally high, making this protocol extremely useful for the synthesis of enantiomerically pure α-substituted ketones. Additionally, not only N-, but also S-, O-, or C-nucleophiles were applicable to this method.
#
#