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Four New DNA Building Blocks
Hachimoji DNA and RNA: A Genetic System with Eight Building Blocks.
15 April 2019 (online)
An artificial genetic system, hachimoji DNA (from Japanese ‘eight letters’) has been obtained using novel nucleotides P, B, Z, and S in combination with standard nucleotides. Hachimoji DNA builds structures with properties similar to those of natural DNA and can be transcribed into hachimoji RNA.
The synthesis of hachimoji DNA involves the novel purines P and B and the pyrimidines Z and S analogues. The representative synthesis of dS phosphoramidite was reported previously by Benner and co-workers in Bioorg. Med. Chem. 2009, 17, 3728.