Synfacts 2019; 15(05): 0555
DOI: 10.1055/s-0037-1612507
Chemistry in Medicine and Biology
© Georg Thieme Verlag Stuttgart · New York

Four New DNA Building Blocks

Dirk Trauner
Andrej Shemet
Hoshika S, Leal NA, Kim M.-J, Kim M.-S, Karalkar NB, Kim H.-J, Bates AM, Watkins NE. J, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia JJ, Georgiadis MM, Benner SA. * Firebird Biomolecular Sciences LLC and Foundation for Applied Molecular Evolution, Alachua, Indiana University School of Medicine, University of Chicago University of Texas, Austin, and DNA Software Inc., Ann Arbor, USA
Hachimoji DNA and RNA: A Genetic System with Eight Building Blocks.

Science 2019;
363: 884-887
Further Information

Publication History

Publication Date:
15 April 2019 (online)



An artificial genetic system, hachimoji DNA (from Japanese ‘eight letters’) has been obtained using novel nucleotides P, B, Z, and S in combination with standard nucleotides. Hachimoji DNA builds structures with properties similar to those of natural DNA and can be transcribed into hachimoji RNA.



The synthesis of hachimoji DNA involves the novel purines P and B and the pyrimidines Z and S analogues. The representative synthesis of dS phosphoramidite was reported previously by Benner and co-workers in Bioorg. Med. Chem. 2009, 17, 3728.