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Synfacts 2019; 15(06): 0681
DOI: 10.1055/s-0037-1612573
DOI: 10.1055/s-0037-1612573
Chemistry in Medicine and Biology
Development of Fluorescent Ca2+ Sensors
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2019 (online)
Significance
Calcium sensors such as indo 1 are routinely used in biological research to monitor calcium mobilization. Calcium can be mobilized from various subcellular compartments (e.g., ER, lysosomes, or mitochondria) and via different mechanisms (e.g., activation of Gq-coupled GPCRs or ion channels).
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Comment
Indo 1 and five other fluorescent calcium indicators were synthesized through related synthetic routes. They can be easily converted into AM-Dyes. The general synthesis of AM-Dyes was published in Nature 1981, 290, 527–528.
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