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DOI: 10.1055/s-0038-1626410
Periodische Hypersomnie
Kasuistik mit biochemischen BefundenPeriodic hypersomniaCase report with biochemical findingsPublication History
Publication Date:
19 January 2018 (online)
Zusammenfassung
Wir berichten über den bisher neunjährigen Verlauf einer periodischen Hypersomnie bei einem 28-jährigen Mann. Die Symptomatik entspricht weitgehend dem Vollbild eines Kleine-Levin-Syndroms. Während der Schlafperioden wurde bei dem Patienten mehrfach eine Erhöhung des Leucin-Enkephalins im Serum beobachtet. Das Opioidpeptid Leucin-Enkephalin kann für das Verständnis der Ätiologie der periodischen Hypersomnie von Bedeutung sein. Weitere biochemische Parameter wie Melatonin und Thyreotropin lagen im Normbereich.
Summary
We report on a nine year course of periodic hypersomnia. In most respects the symptoms fulfil the criteria of a typical Kleine-Levin-syndrome. During different periods of hypersomnia leucine-enkephalin was elevated in serum. The opioid peptide leucine-enkephalin may be important for the understanding of the etiology of periodic hypersomnia. Other clinical chemical parameters like melatonin and thyrotropin were within the limits of normal.
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