Na+/H+-Austausch und Thrombozytenaktivierung

W. Siffert

doi:10.1055/s-0038-1660546

Hämostaseologie, Table of Contents

Hamostaseologie 1987; 07(06): 147-150
DOI: 10.1055/s-0038-1660546

Originalarbeit

Schattauer GmbH

Na⁺/H⁺-Austausch und Thrombozytenaktivierung

W. Siffert

¹Institut für Physiologie, Ruhr-Universität, Bochum

› Author Affiliations

Abstract

Zusammenfassung

Die Stimulation von Thrombozyten mit Thrombin führt zur Erhöhung von pH_i. Diese Alkalisierung des Zytoplasmas wird durch die Aktivität eines Na⁺/H⁺-Austauschers in der Plasmamembran bewirkt. Vermutlich katalysiert die Proteinkinase C die Phosphorylierung dieses Transportsystems. Die Erhöhung von pH_i ist eine wichtige Voraussetzung für die IP₃-induzierte Ca²⁺-Freisetzung aus intrazellulären Speichern und damit unerläßlich für die Thrombozytenaktivierung (Abb. 5).

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References

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