Clin Colon Rectal Surg 2019; 32(04): 280-290
DOI: 10.1055/s-0039-1683917
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Is There a Role for Ileal Pouch Anal Anastomosis in Crohn's Disease?

Nicole E. Lopez
1   Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California
,
Karen Zaghyian
1   Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California
,
Phillip Fleshner
1   Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California
› Author Affiliations
Further Information

Publication History

Publication Date:
17 June 2019 (online)

Abstract

Traditionally, surgical interventions for colonic Crohn's disease (CD) have been limited to total abdominal colectomy and ileorectal anastomosis, or total proctocolectomy with end ileostomy if there is rectal involvement. However, improved understandings of the biology of CD, as well as the development of biologic therapies, have enabled more limited resections. Here, we review the indications for, and limitations of, specific procedures aiming to preserve intestinal continuity in colonic CD.

 
  • References

  • 1 Hyman NH, Fazio VW, Tuckson WB, Lavery IC. Consequences of ileal pouch-anal anastomosis for Crohn's colitis. Dis Colon Rectum 1991; 34 (08) 653-657
  • 2 Deutsch AA, McLeod RS, Cullen J, Cohen Z. Results of the pelvic-pouch procedure in patients with Crohn's disease. Dis Colon Rectum 1991; 34 (06) 475-477
  • 3 Grobler SP, Hosie KB, Affie E, Thompson H, Keighley MR. Outcome of restorative proctocolectomy when the diagnosis is suggestive of Crohn's disease. Gut 1993; 34 (10) 1384-1388
  • 4 Sagar PM, Dozois RR, Wolff BG. Long-term results of ileal pouch-anal anastomosis in patients with Crohn's disease. Dis Colon Rectum 1996; 39 (08) 893-898
  • 5 Peyrègne V, Francois Y, Gilly FN, Descos JL, Flourie B, Vignal J. Outcome of ileal pouch after secondary diagnosis of Crohn's disease. Int J Colorectal Dis 2000; 15 (01) 49-53
  • 6 Mylonakis E, Allan RN, Keighley MR. How does pouch construction for a final diagnosis of Crohn's disease compare with ileoproctostomy for established Crohn's proctocolitis?. Dis Colon Rectum 2001; 44 (08) 1137-1142 , discussion 1142–1143
  • 7 Hartley JE, Fazio VW, Remzi FH. , et al. Analysis of the outcome of ileal pouch-anal anastomosis in patients with Crohn's disease. Dis Colon Rectum 2004; 47 (11) 1808-1815
  • 8 Brown CJ, Maclean AR, Cohen Z, Macrae HM, O'Connor BI, McLeod RS. Crohn's disease and indeterminate colitis and the ileal pouch-anal anastomosis: outcomes and patterns of failure. Dis Colon Rectum 2005; 48 (08) 1542-1549
  • 9 Tekkis PP, Heriot AG, Smith O, Smith JJ, Windsor AC, Nicholls RJ. Long-term outcomes of restorative proctocolectomy for Crohn's disease and indeterminate colitis. Colorectal Dis 2005; 7 (03) 218-223
  • 10 Panis Y, Poupard B, Nemeth J, Lavergne A, Hautefeuille P, Valleur P. Ileal pouch/anal anastomosis for Crohn's disease. Lancet 1996; 347 (9005): 854-857
  • 11 Regimbeau JM, Panis Y, Pocard M. , et al. Long-term results of ileal pouch-anal anastomosis for colorectal Crohn's disease. Dis Colon Rectum 2001; 44 (06) 769-778
  • 12 Melton GB, Fazio VW, Kiran RP. , et al. Long-term outcomes with ileal pouch-anal anastomosis and Crohn's disease: pouch retention and implications of delayed diagnosis. Ann Surg 2008; 248 (04) 608-616
  • 13 Shen B, Patel S, Lian L. Natural history of Crohn's disease in patients who underwent intentional restorative proctocolectomy with ileal pouch-anal anastomosis. Aliment Pharmacol Ther 2010; 31 (07) 745-753
  • 14 Le Q, Melmed G, Dubinsky M. , et al. Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease. Inflamm Bowel Dis 2013; 19 (01) 30-36
  • 15 Farmer M, Petras RE, Hunt LE, Janosky JE, Galandiuk S. The importance of diagnostic accuracy in colonic inflammatory bowel disease. Am J Gastroenterol 2000; 95 (11) 3184-3188
  • 16 Odze RD. A contemporary and critical appraisal of ‘indeterminate colitis’. Mod Pathol 2015; 28 (Suppl. 01) S30-S46
  • 17 Geboes K, Colombel JF, Greenstein A. , et al; Pathology Task Force of the International Organization of Inflammatory Bowel Diseases. Indeterminate colitis: a review of the concept--what's in a name?. Inflamm Bowel Dis 2008; 14 (06) 850-857
  • 18 Silverberg MS, Satsangi J, Ahmad T. , et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19 (Suppl A): 5A-36A
  • 19 Swan NC, Geoghegan JG, O'Donoghue DP, Hyland JM, Sheahan K. Fulminant colitis in inflammatory bowel disease: detailed pathologic and clinical analysis. Dis Colon Rectum 1998; 41 (12) 1511-1515
  • 20 Koltun WA, Schoetz Jr DJ, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC. Indeterminate colitis predisposes to perineal complications after ileal pouch-anal anastomosis. Dis Colon Rectum 1991; 34 (10) 857-860
  • 21 Atkinson KG, Owen DA, Wankling G. Restorative proctocolectomy and indeterminate colitis. Am J Surg 1994; 167 (05) 516-518
  • 22 McIntyre PB, Pemberton JH, Wolff BG, Dozois RR, Beart Jr RW. Indeterminate colitis. Long-term outcome in patients after ileal pouch-anal anastomosis. Dis Colon Rectum 1995; 38 (01) 51-54
  • 23 Marcello PW, Schoetz Jr DJ, Roberts PL. , et al. Evolutionary changes in the pathologic diagnosis after the ileoanal pouch procedure. Dis Colon Rectum 1997; 40 (03) 263-269
  • 24 Yu CS, Pemberton JH, Larson D. Ileal pouch-anal anastomosis in patients with indeterminate colitis: long-term results. Dis Colon Rectum 2000; 43 (11) 1487-1496
  • 25 Pezim ME, Pemberton JH, Beart Jr. RW. , et al. Outcome of “indeterminant” colitis following ileal pouch-anal anastomosis. Dis Colon Rectum 1989; 32 (08) 653-658
  • 26 Dayton MT, Larsen KR, Christiansen DD. Similar functional results and complications after ileal pouch-anal anastomosis in patients with indeterminate vs ulcerative colitis. Arch Surg 2002; 137 (06) 690-694 , discussion 694–695
  • 27 Delaney CP, Remzi FH, Gramlich T, Dadvand B, Fazio VW. Equivalent function, quality of life and pouch survival rates after ileal pouch-anal anastomosis for indeterminate and ulcerative colitis. Ann Surg 2002; 236 (01) 43-48
  • 28 Murrell ZA, Melmed GY, Ippoliti A. , et al. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Dis Colon Rectum 2009; 52 (05) 872-878
  • 29 Jackson KL, Stocchi L, Duraes L, Rencuzogullari A, Bennett AE, Remzi FH. Long-term outcomes in indeterminate colitis patients undergoing ileal pouch-anal anastomosis: function, quality of life, and complications. J Gastrointest Surg 2017; 21 (01) 56-61
  • 30 Fazio VW, Ziv Y, Church JM. , et al. Ileal pouch-anal anastomoses complications and function in 1005 patients. Ann Surg 1995; 222 (02) 120-127
  • 31 Foley EF, Schoetz Jr DJ, Roberts PL. , et al. Rediversion after ileal pouch-anal anastomosis. Causes of failures and predictors of subsequent pouch salvage. Dis Colon Rectum 1995; 38 (08) 793-798
  • 32 Meagher AP, Farouk R, Dozois RR, Kelly KA, Pemberton JH. J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients. Br J Surg 1998; 85 (06) 800-803
  • 33 Michelassi F, Lee J, Rubin M. , et al. Long-term functional results after ileal pouch anal restorative proctocolectomy for ulcerative colitis: a prospective observational study. Ann Surg 2003; 238 (03) 433-441 , discussion 442–445
  • 34 Hahnloser D, Pemberton JH, Wolff BG, Larson DR, Crownhart BS, Dozois RR. Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis. Br J Surg 2007; 94 (03) 333-340
  • 35 Shen B, Fazio VW, Remzi FH. , et al. Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis. Clin Gastroenterol Hepatol 2006; 4 (01) 81-89 , quiz 2–3
  • 36 Shen B, Remzi FH, Hammel JP. , et al. Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch. Inflamm Bowel Dis 2009; 15 (02) 163-170
  • 37 Alexander F, Sarigol S, DiFiore J. , et al. Fate of the pouch in 151 pediatric patients after ileal pouch anal anastomosis. J Pediatr Surg 2003; 38 (01) 78-82
  • 38 Shen B, Fazio VW, Remzi FH. , et al. Risk factors for clinical phenotypes of Crohn's disease of the ileal pouch. Am J Gastroenterol 2006; 101 (12) 2760-2768
  • 39 Melmed GY, Fleshner PR, Bardakcioglu O. , et al. Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum 2008; 51 (01) 100-108
  • 40 Zaghiyan K, Kamiński JP, Barmparas G, Fleshner P. De novo Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified: long-term follow-up of a Prospective Inflammatory Bowel Disease Registry. Am Surg 2016; 82 (10) 977-981
  • 41 Shen B. Crohn's disease of the ileal pouch: reality, diagnosis, and management. Inflamm Bowel Dis 2009; 15 (02) 284-294
  • 42 Tekkis PP, Purkayastha S, Lanitis S. , et al. A comparison of segmental vs subtotal/total colectomy for colonic Crohn's disease: a meta-analysis. Colorectal Dis 2006; 8 (02) 82-90
  • 43 Colombel JF, Ricart E, Loftus Jr EV. , et al. Management of Crohn's disease of the ileoanal pouch with infliximab. Am J Gastroenterol 2003; 98 (10) 2239-2244
  • 44 Viscido A, Habib FI, Kohn A. , et al. Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis. Aliment Pharmacol Ther 2003; 17 (10) 1263-1271
  • 45 Calabrese C, Gionchetti P, Rizzello F. , et al. Short-term treatment with infliximab in chronic refractory pouchitis and ileitis. Aliment Pharmacol Ther 2008; 27 (09) 759-764
  • 46 Shen B, Remzi FH, Lavery IC. , et al. Administration of adalimumab in the treatment of Crohn's disease of the ileal pouch. Aliment Pharmacol Ther 2009; 29 (05) 519-526
  • 47 Ferrante M, D'Haens G, Dewit O. , et al; Belgian IBD Research Group. Efficacy of infliximab in refractory pouchitis and Crohn's disease-related complications of the pouch: a Belgian case series. Inflamm Bowel Dis 2010; 16 (02) 243-249
  • 48 Haveran LA, Sehgal R, Poritz LS, McKenna KJ, Stewart DB, Koltun WA. Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA. Dis Colon Rectum 2011; 54 (01) 15-20
  • 49 Li Y, Lopez R, Queener E, Shen B. Adalimumab therapy in Crohn's disease of the ileal pouch. Inflamm Bowel Dis 2012; 18 (12) 2232-2239
  • 50 Robbins L, Zaghiyan K, Melmed G. , et al. Outcomes with anti-tumour necrosis factor-alpha therapy and serology in patients with de novo Crohn's disease after ileal pouch anal anastomosis. J Crohn's Colitis 2017; 11 (01) 77-83
  • 51 Yamamoto T, Keighley MR. Proctocolectomy is associated with a higher complication rate but carries a lower recurrence rate than total colectomy and ileorectal anastomosis in Crohn colitis. Scand J Gastroenterol 1999; 34 (12) 1212-1215
  • 52 Yamamoto T, Bain IM, Allan RN, Keighley MR. Persistent perineal sinus after proctocolectomy for Crohn's disease. Dis Colon Rectum 1999; 42 (01) 96-101
  • 53 O'Riordan JM, O'Connor BI, Huang H. , et al. Long-term outcome of colectomy and ileorectal anastomosis for Crohn's colitis. Dis Colon Rectum 2011; 54 (11) 1347-1354
  • 54 Angriman I, Pirozzolo G, Bardini R, Cavallin F, Castoro C, Scarpa M. A systematic review of segmental vs subtotal colectomy and subtotal colectomy vs total proctocolectomy for colonic Crohn's disease. Colorectal Dis 2017; 19 (08) e279-e287
  • 55 Longo WE, Oakley JR, Lavery IC, Church JM, Fazio VW. Outcome of ileorectal anastomosis for Crohn's colitis. Dis Colon Rectum 1992; 35 (11) 1066-1071
  • 56 Kariv Y, Remzi FH, Strong SA, Hammel JP, Preen M, Fazio VW. Ileal pouch rectal anastomosis: a viable alternative to permanent ileostomy in Crohn's proctocolitis patients. J Am Coll Surg 2009; 208 (03) 390-399
  • 57 de Oca J, Sánchez-Santos R, Ragué JM. , et al. Long-term results of ileal pouch-anal anastomosis in Crohn's disease. Inflamm Bowel Dis 2003; 9 (03) 171-175
  • 58 Braveman JM, Schoetz Jr DJ, Marcello PW. , et al. The fate of the ileal pouch in patients developing Crohn's disease. Dis Colon Rectum 2004; 47 (10) 1613-1619
  • 59 Rudolph WG, Uthoff SM, McAuliffe TL, Goode ET, Petras RE, Galandiuk S. Indeterminate colitis: the real story. Dis Colon Rectum 2002; 45 (11) 1528-1534
  • 60 Pishori T, Dinnewitzer A, Zmora O. , et al. Outcome of patients with indeterminate colitis undergoing a double-stapled ileal pouch-anal anastomosis. Dis Colon Rectum 2004; 47 (05) 717-721