Ototoxicity: Visualized in Concept Maps

Abstract

Ototoxicity refers to the damage to structures and function of the auditory-vestibular system caused by exogenous agents such as pharmaceuticals, chemicals, and ionizing radiation. There are many potentially ototoxic substances. For example, depending on how ototoxicity is defined, there are 200 to 600 medications that can cause damage to hearing and/or balance. Ototoxicity encompasses cochleotoxicity, vestibulotoxicity, and neurotoxicity. A variety of professional disciplines are involved in determining causation, prevention, and management of ototoxic effects. Research to identify and develop otoprotectants and otorescue agents is emerging and will translate basic scientific discovery into applications for use in hearing conservation programs, safety operations, and clinical care. Original concept maps are presented here to visually represent knowledge pathways, domains, and relationships essential to the understanding of ototoxicity.

Keywords

concept map - ototoxicity - ototoxins - ototoxicity monitoring

Disclaimers

The author currently serves as the cochair/administrator for the DoD HCE PIHL Ototoxicity Committee.

The author is a contractor, not a Federal employee. No financial conflicts of interest exist. The information presented and the opinions expressed herein are those of the author and do not necessarily reflect the position or policy of the Department of Defense or the U.S. government.

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