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Synfacts 2020; 16(04): 0477
DOI: 10.1055/s-0039-1690068
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Boronic Acid Catalyzed Dehydrative Peptide Synthesis

Contributor(s):
Hisashi Yamamoto
,
Wataru Muramatsu
Michigami K, Sakaguchi T, Takemoto Y. * Kyoto University, Japan
Catalytic Dehydrative Peptide Synthesis with gem-Diboronic Acids.

ACS Catal. 2020;
10: 683-688
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Further Information

Publication History

Publication Date:
18 March 2020 (online)

 
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Key words

diboronic acids - amidation - amino acids - peptides

Significance

The amide group is an essential functional groups that exists ubiquitously in natural products, pharmaceuticals, and the like. The authors describe a boronic acid catalyzed dehydrative amidation of amino acids.


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Comment

This amide bond formation from amino acids catalyzed by a gem-diboronic acid proceeds smoothly to give the desired peptides in moderate to high yields without significant loss of stereochemical integrity.


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