Thermal Ablation of Metastatic Colon Cancer to the Liver

Abstract

Colorectal cancer (CRC) is responsible for approximately 10% of cancer-related deaths in the Western world. Liver metastases are frequently seen at the time of diagnosis and throughout the course of the disease. Surgical resection is often considered as it provides long-term survival; however, few patients are candidates for resection. Percutaneous ablative therapies are also used in the management of this patient population. Different thermal ablation (TA) technologies are available including radiofrequency ablation, microwave ablation (MWA), laser, and cryoablation. There is growing evidence about the role of interventional oncology and image-guided percutaneous ablation in the management of metastatic colorectal liver disease. This article aims to outline the technical considerations, outcomes, and rational of TA in the management of patients with CRC liver metastases, focusing on the emerging role of MWA.

Keywords

metastatic colon cancer - liver metastasis - thermal ablation - survival

• References

• 1 Renehan AG, Egger M, Saunders MP, O'Dwyer ST. Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials. BMJ 2002; 324 (7341): 813
• 2 Hanna NN. Radiofrequency ablation of primary and metastatic hepatic malignancies. Clin Colorectal Cancer 2004; 4 (02) 92-100
• 3 Vogl TJ, Farshid P, Naguib NN. , et al. Thermal ablation of liver metastases from colorectal cancer: radiofrequency, microwave and laser ablation therapies. Radiol Med (Torino) 2014; 119 (07) 451-461
• 4 Engstrom PF, Arnoletti JP, Benson III AB. , et al; National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: rectal cancer. J Natl Compr Canc Netw 2009; 7 (08) 838-881
• 5 Ikoma N, Raghav K, Chang G. An update on randomized clinical trials in metastatic colorectal carcinoma. Surg Oncol Clin N Am 2017; 26 (04) 667-687
• 6 Ruers T, Van Coevorden F, Punt CJ. , et al; European Organisation for Research and Treatment of Cancer (EORTC); Gastro-Intestinal Tract Cancer Group; Arbeitsgruppe Lebermetastasen und tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); National Cancer Research Institute Colorectal Clinical Study Group (NCRI CCSG). Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial. J Natl Cancer Inst 2017; 109 (09)
• 7 Eltawil KM, Boame N, Mimeault R. , et al. Patterns of recurrence following selective intraoperative radiofrequency ablation as an adjunct to hepatic resection for colorectal liver metastases. J Surg Oncol 2014; 110 (06) 734-738
• 8 Faitot F, Faron M, Adam R. , et al. Two-stage hepatectomy versus 1-stage resection combined with radiofrequency for bilobar colorectal metastases: a case-matched analysis of surgical and oncological outcomes. Ann Surg 2014; 260 (05) 822-827 , discussion 827–828
• 9 Karanicolas PJ, Jarnagin WR, Gonen M. , et al. Long-term outcomes following tumor ablation for treatment of bilateral colorectal liver metastases. JAMA Surg 2013; 148 (07) 597-601
• 10 Meijerink MR, Puijk RS, van Tilborg AAJM. , et al. Radiofrequency and microwave ablation compared to systemic chemotherapy and to partial hepatectomy in the treatment of colorectal liver metastases: a systematic review and meta-analysis. Cardiovasc Intervent Radiol 2018; 41 (08) 1189-1204
• 11 Benson III AB, D'Angelica MI, Abbott DE. , et al. NCCN guidelines insights: hepatobiliary cancers, version 1.2017. J Natl Compr Canc Netw 2017; 15 (05) 563-573
• 12 Benson III AB, Venook AP, Cederquist L. , et al. Colon cancer, version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2017; 15 (03) 370-398
• 13 Kanas GP, Taylor A, Primrose JN. , et al. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clin Epidemiol 2012; 4: 283-301
• 14 Aloia TA, Vauthey JN, Loyer EM. , et al. Solitary colorectal liver metastasis: resection determines outcome. Arch Surg 2006; 141 (05) 460-466 , discussion 466–467
• 15 Pawlik TM, Schulick RD, Choti MA. Expanding criteria for resectability of colorectal liver metastases. Oncologist 2008; 13 (01) 51-64
• 16 Nakamura S, Suzuki S, Konno H. Resection of hepatic metastases of colorectal carcinoma: 20 years' experience. J Hepatobiliary Pancreat Surg 1999; 6 (01) 16-22
• 17 Suzuki S, Sakaguchi T, Yokoi Y. , et al. Impact of repeat hepatectomy on recurrent colorectal liver metastases. Surgery 2001; 129 (04) 421-428
• 18 Yokoi Y, Suzuki S, Nakamura S. The impact of hepatic resection on metastatic colorectal cancer. Gan To Kagaku Ryoho 2002; 29 (06) 848-855
• 19 Schüle S, Dittmar Y, Knösel T. , et al. Long-term results and prognostic factors after resection of hepatic and pulmonary metastases of colorectal cancer. Int J Colorectal Dis 2013; 28 (04) 537-545
• 20 Adams RB, Aloia TA, Loyer E, Pawlik TM, Taouli B, Vauthey JN. ; Americas Hepato-Pancreato-Biliary Association; Society of Surgical Oncology; Society for Surgery of the Alimentary Tract. Selection for hepatic resection of colorectal liver metastases: expert consensus statement. HPB (Oxford) 2013; 15 (02) 91-103
• 21 Lee MT, Kim JJ, Dinniwell R. , et al. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol 2009; 27 (10) 1585-1591
• 22 Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999; 230 (03) 309-318 , discussion 318–321
• 23 Gillams A, Goldberg N, Ahmed M. , et al. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, The Interventional Oncology Sans Frontières meeting 2013. Eur Radiol 2015; 25 (12) 3438-3454
• 24 Livraghi T, Solbiati L, Meloni F, Ierace T, Goldberg SN, Gazelle GS. Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the “test-of-time approach”. Cancer 2003; 97 (12) 3027-3035
• 25 Puijk RS, Ruarus AH, Vroomen LGPH. , et al; COLLISION Trial Group. Colorectal liver metastases: surgery versus thermal ablation (COLLISION) - a phase III single-blind prospective randomized controlled trial. BMC Cancer 2018; 18 (01) 821
• 26 Goldberg SN, Gazelle GS, Halpern EF, Rittman WJ, Mueller PR, Rosenthal DI. Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size. Acad Radiol 1996; 3 (03) 212-218
• 27 Haemmerich D, Pilcher TA. Convective cooling affects cardiac catheter cryoablation and radiofrequency ablation in opposite directions. Conf Proc IEEE Eng Med Biol Soc 2007; 2007: 1499-1502
• 28 Wolf FJ, Grand DJ, Machan JT, Dipetrillo TA, Mayo-Smith WW, Dupuy DE. Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients. Radiology 2008; 247 (03) 871-879
• 29 Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee Jr FT. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 2005; 236 (01) 132-139
• 30 Yang D, Converse MC, Mahvi DM, Webster JG. Measurement and analysis of tissue temperature during microwave liver ablation. IEEE Trans Biomed Eng 2007; 54 (01) 150-155
• 31 Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW, Lee Jr FT. Microwave ablation with a single small-gauge triaxial antenna: in vivo porcine liver model. Radiology 2007; 242 (02) 435-440
• 32 Walser EM. Percutaneous laser ablation in the treatment of hepatocellular carcinoma with a tumor size of 4 cm or smaller: analysis of factors affecting the achievement of tumor necrosis. J Vasc Interv Radiol 2005; 16 (11) 1427-1429
• 33 Stollberger R, Ascher PW, Huber D, Renhart W, Radner H, Ebner F. Temperature monitoring of interstitial thermal tissue coagulation using MR phase images. J Magn Reson Imaging 1998; 8 (01) 188-196
• 34 Skinner MG, Iizuka MN, Kolios MC, Sherar MD. A theoretical comparison of energy sources--microwave, ultrasound and laser--for interstitial thermal therapy. Phys Med Biol 1998; 43 (12) 3535-3547
• 35 Heisterkamp J, van Hillegersberg R, Sinofsky E, IJzermans JN. Heat-resistant cylindrical diffuser for interstitial laser coagulation: comparison with the bare-tip fiber in a porcine liver model. Lasers Surg Med 1997; 20 (03) 304-309
• 36 Georgiades CS, Hong K, Bizzell C, Geschwind JF, Rodriguez R. Safety and efficacy of CT-guided percutaneous cryoablation for renal cell carcinoma. J Vasc Interv Radiol 2008; 19 (09) 1302-1310
• 37 Permpongkosol S, Nicol TL, Link RE. , et al. Differences in ablation size in porcine kidney, liver, and lung after cryoablation using the same ablation protocol. AJR Am J Roentgenol 2007; 188 (04) 1028-1032
• 38 Yu H, Burke CT. Comparison of percutaneous ablation technologies in the treatment of malignant liver tumors. Semin Intervent Radiol 2014; 31 (02) 129-137
• 39 Tanis E, Nordlinger B, Mauer M. , et al. Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983. Eur J Cancer 2014; 50 (05) 912-919
• 40 Ruers T, Punt C, Van Coevorden F. , et al; EORTC Gastro-Intestinal Tract Cancer Group, Arbeitsgruppe Lebermetastasen und—tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO) and the National Cancer Research Institute Colorectal Clinical Study Group (NCRI CCSG). Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol 2012; 23 (10) 2619-2626
• 41 Sotirchos VS, Petrovic LM, Gönen M. , et al. Colorectal cancer liver metastases: biopsy of the ablation zone and margins can be used to predict oncologic outcome. Radiology 2016; 280 (03) 949-959
• 42 Sofocleous CT, Petre EN, Gonen M. , et al. CT-guided radiofrequency ablation as a salvage treatment of colorectal cancer hepatic metastases developing after hepatectomy. J Vasc Interv Radiol 2011; 22 (06) 755-761
• 43 Shady W, Petre EN, Gonen M. , et al. Percutaneous radiofrequency ablation of colorectal cancer liver metastases: factors affecting outcomes--a 10-year experience at a single center. Radiology 2016; 278 (02) 601-611
• 44 Wang X, Sofocleous CT, Erinjeri JP. , et al. Margin size is an independent predictor of local tumor progression after ablation of colon cancer liver metastases. Cardiovasc Intervent Radiol 2013; 36 (01) 166-175
• 45 Odisio BC, Yamashita S, Huang SY. , et al. Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. Br J Surg 2017; 104 (06) 760-768
• 46 Calandri M, Yamashita S, Gazzera C. , et al. Ablation of colorectal liver metastasis: Interaction of ablation margins and RAS mutation profiling on local tumour progression-free survival. Eur Radiol 2018; 28 (07) 2727-2734
• 47 Shady W, Petre EN, Do KG. , et al. Percutaneous microwave versus radiofrequency ablation of colorectal liver metastases: ablation with clear margins (A0) provides the best local tumor control. J Vasc Interv Radiol 2018; 29 (02) 268-275.e1
• 48 Shady W, Petre EN, Vakiani E. , et al. Kras mutation is a marker of worse oncologic outcomes after percutaneous radiofrequency ablation of colorectal liver metastases. Oncotarget 2017; 8 (39) 66117-66127
• 49 Ranpura V, Hapani S, Wu S. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 2011; 305 (05) 487-494
• 50 Vigano L, De Rosa G, Toso C. , et al. Reversibility of chemotherapy-related liver injury. J Hepatol 2017; 67 (01) 84-91
• 51 Brown KT, Kemeny N, Berger MF. , et al. Obstructive jaundice in patients receiving hepatic artery infusional chemotherapy: etiology, treatment implications, and complications after transhepatic biliary drainage. J Vasc Interv Radiol 1997; 8 (02) 229-234
• 52 Pien EH, Zeman RK, Benjamin SB. , et al. Iatrogenic sclerosing cholangitis following hepatic arterial chemotherapy infusion. Radiology 1985; 156 (02) 329-330
• 53 Botet JF, Watson RC, Kemeny N, Daly JM, Yeh S. Cholangitis complicating intraarterial chemotherapy in liver metastasis. Radiology 1985; 156 (02) 335-337
• 54 Kang TW, Rhim H. Recent advances in tumor ablation for hepatocellular carcinoma. Liver Cancer 2015; 4 (03) 176-187
• 55 Hasegawa T, Takaki H, Miyagi H. , et al. Hyaluronic acid gel injection to prevent thermal injury of adjacent gastrointestinal tract during percutaneous liver radiofrequency ablation. Cardiovasc Intervent Radiol 2013; 36 (04) 1144-1146
• 56 Kang TW, Rhim H, Lee MW. , et al. Radiofrequency ablation for hepatocellular carcinoma abutting the diaphragm: comparison of effects of thermal protection and therapeutic efficacy. AJR Am J Roentgenol 2011; 196 (04) 907-913
• 57 Bhatia SS, Spector S, Echenique A. , et al. Is antibiotic prophylaxis for percutaneous radiofrequency ablation (RFA) of primary liver tumors necessary? Results from a single-center experience. Cardiovasc Intervent Radiol 2015; 38 (04) 922-928
• 58 Venkatesan AM, Kundu S, Sacks D. , et al; Society of Interventional Radiology Standards of Practice Committee. Practice guidelines for adult antibiotic prophylaxis during vascular and interventional radiology procedures [corrected]. J Vasc Interv Radiol 2010; 21 (11) 1611-1630 , quiz 1631
• 59 Hoffmann R, Rempp H, Schmidt D, Pereira PL, Claussen CD, Clasen S. Prolonged antibiotic prophylaxis in patients with bilioenteric anastomosis undergoing percutaneous radiofrequency ablation. J Vasc Interv Radiol 2012; 23 (04) 545-551
• 60 Khan W, Sullivan KL, McCann JW. , et al. Moxifloxacin prophylaxis for chemoembolization or embolization in patients with previous biliary interventions: a pilot study. AJR Am J Roentgenol 2011; 197 (02) W343-345
• 61 Kuvshinoff BW, Ota DM. Radiofrequency ablation of liver tumors: influence of technique and tumor size. Surgery 2002; 132 (04) 605-611 , discussion 611–612
• 62 Ahmed M, Solbiati L, Brace CL. , et al; International Working Group on Image-guided Tumor Ablation; Interventional Oncology Sans Frontières Expert Panel; Technology Assessment Committee of the Society of Interventional Radiology; Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe. Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update. Radiology 2014; 273 (01) 241-260
• 63 Kim YS, Rhim H, Cho OK, Koh BH, Kim Y. Intrahepatic recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: analysis of the pattern and risk factors. Eur J Radiol 2006; 59 (03) 432-441
• 64 Kim YS, Lee WJ, Rhim H, Lim HK, Choi D, Lee JY. The minimal ablative margin of radiofrequency ablation of hepatocellular carcinoma (> 2 and < 5 cm) needed to prevent local tumor progression: 3D quantitative assessment using CT image fusion. AJR Am J Roentgenol 2010; 195 (03) 758-765
• 65 Liu CH, Arellano RS, Uppot RN, Samir AE, Gervais DA, Mueller PR. Radiofrequency ablation of hepatic tumours: effect of post-ablation margin on local tumour progression. Eur Radiol 2010; 20 (04) 877-885
• 66 Nakazawa T, Kokubu S, Shibuya A. , et al. Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin. AJR Am J Roentgenol 2007; 188 (02) 480-488
• 67 Teng W, Liu KW, Lin CC. , et al. Insufficient ablative margin determined by early computed tomography may predict the recurrence of hepatocellular carcinoma after radiofrequency ablation. Liver Cancer 2015; 4 (01) 26-38
• 68 Bo XW, Xu HX, Wang D. , et al. Fusion imaging of contrast-enhanced ultrasound and contrast-enhanced CT or MRI before radiofrequency ablation for liver cancers. Br J Radiol 2016; 89 (1067): 20160379
• 69 Xu EJ, Lv SM, Li K. , et al. Immediate evaluation and guidance of liver cancer thermal ablation by three-dimensional ultrasound/contrast-enhanced ultrasound fusion imaging. Int J Hyperthermia 2018; 34 (06) 870-876
• 70 Mauri G, Porazzi E, Cova L. , et al. Intraprocedural contrast-enhanced ultrasound (CEUS) in liver percutaneous radiofrequency ablation: clinical impact and health technology assessment. Insights Imaging 2014; 5 (02) 209-216
• 71 Meloni MF, Andreano A, Franza E, Passamonti M, Lazzaroni S. Contrast enhanced ultrasound: should it play a role in immediate evaluation of liver tumors following thermal ablation?. Eur J Radiol 2012; 81 (08) e897-e902
• 72 Khandani AH, Calvo BF, O'Neil BH, Jorgenson J, Mauro MA. A pilot study of early 18F-FDG PET to evaluate the effectiveness of radiofrequency ablation of liver metastases. AJR Am J Roentgenol 2007; 189 (05) 1199-1202
• 73 Veit P, Antoch G, Stergar H, Bockisch A, Forsting M, Kuehl H. Detection of residual tumor after radiofrequency ablation of liver metastasis with dual-modality PET/CT: initial results. Eur Radiol 2006; 16 (01) 80-87
• 74 Cornelis F, Sotirchos V, Violari E. , et al. 18F-FDG PET/CT is an immediate imaging biomarker of treatment success after liver metastasis ablation. J Nucl Med 2016; 57 (07) 1052-1057
• 75 Ryan ER, Sofocleous CT, Schöder H. , et al. Split-dose technique for FDG PET/CT-guided percutaneous ablation: a method to facilitate lesion targeting and to provide immediate assessment of treatment effectiveness. Radiology 2013; 268 (01) 288-295
• 76 Vogl TJ, Basten LM, Nour-Eldin NA. , et al. Evaluation of microwave ablation of liver malignancy with enabled constant spatial energy control to achieve a predictable spherical ablation zone. Int J Hyperthermia 2018; 34 (04) 492-500
• 77 Kaye EA, Cornelis FH, Petre EN. , et al. Volumetric 3D assessment of ablation zones after thermal ablation of colorectal liver metastases to improve prediction of local tumor progression. Eur Radiol 2019; 29 (05) 2698-2705
• 78 Silverman SG, Sun MR, Tuncali K. , et al. Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases. AJR Am J Roentgenol 2004; 183 (03) 707-712
• 79 Hocquelet A, Trillaud H, Frulio N. , et al. Three-dimensional measurement of hepatocellular carcinoma ablation zones and margins for predicting local tumor progression. J Vasc Interv Radiol 2016; 27 (07) 1038-1045.e2
• 80 Tani S, Tatli S, Hata N. , et al. Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map. Int J CARS 2016; 11 (06) 1133-1142
• 81 Solbiati M, Muglia R, Goldberg SN. , et al. A novel software platform for volumetric assessment of ablation completeness. Int J Hyperthermia 2019; 36 (01) 337-343
• 82 Makino Y, Imai Y, Igura T. , et al. Utility of computed tomography fusion imaging for the evaluation of the ablative margin of radiofrequency ablation for hepatocellular carcinoma and the correlation to local tumor progression. Hepatol Res 2013; 43 (09) 950-958
• 83 Fujioka C, Horiguchi J, Ishifuro M. , et al. A feasibility study: evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT. Acad Radiol 2006; 13 (08) 986-994
• 84 Kim KW, Lee JM, Klotz E. , et al. Safety margin assessment after radiofrequency ablation of the liver using registration of preprocedure and postprocedure CT images. AJR Am J Roentgenol 2011; 196 (05) W565-W572
• 85 Shin S, Lee JM, Kim KW. , et al. Postablation assessment using follow-up registration of CT images before and after radiofrequency ablation (RFA): prospective evaluation of midterm therapeutic results of RFA for hepatocellular carcinoma. AJR Am J Roentgenol 2014; 203 (01) 70-77
• 86 Sakakibara M, Ohkawa K, Katayama K. , et al. Three-dimensional registration of images obtained before and after radiofrequency ablation of hepatocellular carcinoma to assess treatment adequacy. AJR Am J Roentgenol 2014; 202 (05) W487-495
• 87 Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK. Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 2000; 88 (11) 2452-2463
• 88 Hof J, Wertenbroek MW, Peeters PM, Widder J, Sieders E, de Jong KP. Outcomes after resection and/or radiofrequency ablation for recurrence after treatment of colorectal liver metastases. Br J Surg 2016; 103 (08) 1055-1062
• 89 Lee H, Heo JS, Cho YB. , et al. Hepatectomy vs radiofrequency ablation for colorectal liver metastasis: a propensity score analysis. World J Gastroenterol 2015; 21 (11) 3300-3307
• 90 Lee KH, Kim HO, Yoo CH. , et al. Comparison of radiofrequency ablation and resection for hepatic metastasis from colorectal cancer. Korean J Gastroenterol 2012; 59 (03) 218-223
• 91 Lee WS, Yun SH, Chun HK. , et al. Clinical outcomes of hepatic resection and radiofrequency ablation in patients with solitary colorectal liver metastasis. J Clin Gastroenterol 2008; 42 (08) 945-949
• 92 Nishiwada S, Ko S, Mukogawa T. , et al. Comparison between percutaneous radiofrequency ablation and surgical hepatectomy focusing on local disease control rate for colorectal liver metastases. Hepatogastroenterology 2014; 61 (130) 436-441
• 93 Govindarajan A, Arnaoutakis D, D'Angelica M. , et al. Use of intraoperative ablation as an adjunct to surgical resection in the treatment of recurrent colorectal liver metastases. J Gastrointest Surg 2011; 15 (07) 1168-1172
• 94 Abdalla EK, Vauthey JN, Ellis LM. , et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004; 239 (06) 818-825 , discussion 825–827
• 95 Elias D, De Baere T, Smayra T, Ouellet JF, Roche A, Lasser P. Percutaneous radiofrequency thermoablation as an alternative to surgery for treatment of liver tumour recurrence after hepatectomy. Br J Surg 2002; 89 (06) 752-756
• 96 Solbiati L, Ahmed M, Cova L, Ierace T, Brioschi M, Goldberg SN. Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. Radiology 2012; 265 (03) 958-968
• 97 Kim KH, Yoon YS, Yu CS. , et al. Comparative analysis of radiofrequency ablation and surgical resection for colorectal liver metastases. J Korean Surg Soc 2011; 81 (01) 25-34
• 98 Hur H, Ko YT, Min BS. , et al. Comparative study of resection and radiofrequency ablation in the treatment of solitary colorectal liver metastases. Am J Surg 2009; 197 (06) 728-736
• 99 Oshowo A, Gillams A, Harrison E, Lees WR, Taylor I. Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases. Br J Surg 2003; 90 (10) 1240-1243
• 100 Otto G, Düber C, Hoppe-Lotichius M, König J, Heise M, Pitton MB. Radiofrequency ablation as first-line treatment in patients with early colorectal liver metastases amenable to surgery. Ann Surg 2010; 251 (05) 796-803
• 101 Pawlik TM, Tanabe KK. Radiofrequency ablation for primary and metastatic liver tumors. Cancer Treat Res 2001; 109: 247-267
• 102 Kei SK, Rhim H, Choi D, Lee WJ, Lim HK, Kim YS. Local tumor progression after radiofrequency ablation of liver tumors: analysis of morphologic pattern and site of recurrence. AJR Am J Roentgenol 2008; 190 (06) 1544-1551
• 103 Rossi S, Garbagnati F, Lencioni R. , et al. Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology 2000; 217 (01) 119-126
• 104 Mulier S, Ruers T, Jamart J, Michel L, Marchal G, Ni Y. Radiofrequency ablation versus resection for resectable colorectal liver metastases: time for a randomized trial? An update. Dig Surg 2008; 25 (06) 445-460
• 105 Ayav A, Germain A, Marchal F. , et al. Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence. Am J Surg 2010; 200 (04) 435-439
• 106 Mulier S, Ni Y, Jamart J, Ruers T, Marchal G, Michel L. Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann Surg 2005; 242 (02) 158-171
• 107 Lee BC, Lee HG, Park IJ. , et al. The role of radiofrequency ablation for treatment of metachronous isolated hepatic metastasis from colorectal cancer. Medicine (Baltimore) 2016; 95 (39) e4999
• 108 de Jong MC, Pulitano C, Ribero D. , et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 2009; 250 (03) 440-448
• 109 Pawlik TM, Scoggins CR, Zorzi D. , et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 2005; 241 (05) 715-722 , discussion 722–724
• 110 Muratore A, Ribero D, Zimmitti G, Mellano A, Langella S, Capussotti L. Resection margin and recurrence-free survival after liver resection of colorectal metastases. Ann Surg Oncol 2010; 17 (05) 1324-1329
• 111 Solbiati L, Livraghi T, Goldberg SN. , et al. Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 2001; 221 (01) 159-166
• 112 de Baere T, Elias D, Dromain C. , et al. Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. AJR Am J Roentgenol 2000; 175 (06) 1619-1625
• 113 Berber E, Pelley R, Siperstein AE. Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: a prospective study. J Clin Oncol 2005; 23 (07) 1358-1364
• 114 Huo YR, Eslick GD. Microwave ablation compared to radiofrequency ablation for hepatic lesions: a meta-analysis. J Vasc Interv Radiol 2015; 26 (08) 1139-1146.e2
• 115 Correa-Gallego C, Fong Y, Gonen M. , et al. A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases. Ann Surg Oncol 2014; 21 (13) 4278-4283
• 116 Liu Y, Li S, Wan X. , et al. Efficacy and safety of thermal ablation in patients with liver metastases. Eur J Gastroenterol Hepatol 2013; 25 (04) 442-446
• 117 Shibata T, Niinobu T, Ogata N, Takami M. Microwave coagulation therapy for multiple hepatic metastases from colorectal carcinoma. Cancer 2000; 89 (02) 276-284
• 118 van Tilborg AA, Scheffer HJ, de Jong MC. , et al. MWA versus RFA for perivascular and peribiliary CRLM: a retrospective patient- and lesion-based analysis of two historical cohorts. Cardiovasc Intervent Radiol 2016; 39 (10) 1438-1446
• 119 Ierardi AM, Floridi C, Fontana F. , et al. Microwave ablation of liver metastases to overcome the limitations of radiofrequency ablation. Radiol Med (Torino) 2013; 118 (06) 949-961
• 120 Lubner MG, Brace CL, Hinshaw JL, Lee Jr FT. Microwave tumor ablation: mechanism of action, clinical results, and devices. J Vasc Interv Radiol 2010; 21 (8, Suppl): S192-S203
• 121 Alexander ES, Wolf FJ, Machan JT. , et al. Microwave ablation of focal hepatic malignancies regardless of size: a 9-year retrospective study of 64 patients. Eur J Radiol 2015; 84 (06) 1083-1090
• 122 Smith DL, Soria JC, Morat L. , et al. Human telomerase reverse transcriptase (hTERT) and Ki-67 are better predictors of survival than established clinical indicators in patients undergoing curative hepatic resection for colorectal metastases. Ann Surg Oncol 2004; 11 (01) 45-51
• 123 Balachandran VP, Arora A, Gönen M. , et al. A validated prognostic multigene expression assay for overall survival in resected colorectal cancer liver metastases. Clin Cancer Res 2016; 22 (10) 2575-2582
• 124 Ito H, Mo Q, Qin LX. , et al. Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer. PLoS One 2013; 8 (12) e81680
• 125 Kingham TP, Nguyen HCB, Zheng J. , et al. MicroRNA-203 predicts human survival after resection of colorectal liver metastasis. Oncotarget 2017; 8 (12) 18821-18831
• 126 Petrowsky H, Sturm I, Graubitz O. , et al. Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases. Eur J Surg Oncol 2001; 27 (01) 80-87
• 127 Sofocleous CT, Nascimento RG, Petrovic LM. , et al. Histopathologic and immunohistochemical features of tissue adherent to multitined electrodes after RF ablation of liver malignancies can help predict local tumor progression: initial results. Radiology 2008; 249 (01) 364-374
• 128 Sofocleous CT, Garg S, Petrovic LM. , et al. Ki-67 is a prognostic biomarker of survival after radiofrequency ablation of liver malignancies. Ann Surg Oncol 2012; 19 (13) 4262-4269
• 129 Ghosh A, Lai C, McDonald S. , et al. HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53. Exp Mol Pathol 2013; 94 (01) 103-108
• 130 Thompson SM, Callstrom MR, Jondal DE. , et al. Heat stress-induced PI3K/mTORC2-dependent AKT signaling is a central mediator of hepatocellular carcinoma survival to thermal ablation induced heat stress. PLoS One 2016; 11 (09) e0162634