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Synfacts 2021; 17(01): 0111
DOI: 10.1055/s-0040-1706075
DOI: 10.1055/s-0040-1706075
Peptide Chemistry
Peptide Bond Formation by Using p-Nitrophenyl Esters
Gagnon P,
Huang X,
Therrien E,
Keillor JW.
*
Université de Montréal, Canada
Peptide Coupling of Unprotected Amino Acids through in situ p-Nitrophenyl Ester Formation.
Tetrahedron Lett. 2002;
43: 7717-7719
DOI: 10.1016/S0040-4039(02)01840-3.
Peptide Coupling of Unprotected Amino Acids through in situ p-Nitrophenyl Ester Formation.
Tetrahedron Lett. 2002;
43: 7717-7719
DOI: 10.1016/S0040-4039(02)01840-3.
Significance
Reactive amino acid phenyl esters have been used in peptide synthesis. In 2002, Keillor and co-workers reported a method for peptide bond formation between p-nitrophenyl esters and unprotected amino acids in aqueous solution.
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Comment
By using p-nitrophenyl esters formed in situ, various dipeptides or tripeptides were synthesized without classical peptide-coupling reagents. The yields of the target peptides were moderate to excellent.
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Publication History
Article published online:
16 December 2020
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