Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Download PDF
Synfacts 2021; 17(05): 0587
DOI: 10.1055/s-0040-1706184
DOI: 10.1055/s-0040-1706184
Peptide Chemistry
Thiopyridone-Derived Reagents for Peptide Coupling Reactions
Bailén MA,
Chinchilla R,
Dodsworth DJ,
Nájera C.
*
Universidad de Alicante, Spain
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q
Significance
Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Nájera and co-workers reported a method for synthesizing thiopyridone-derived uronium salts as coupling reagents. The reagents were prepared from cheap starting materials, making them more economical than conventional coupling reagents such as HOBt.
MissingLinkText
Comment
By using the thiopyridone-derived reagents as coupling reagents, various dipeptides were synthesized in moderate to excellent yields.
MissingLinkText
MissingLinkText
Publication History
Article published online:
20 April 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany