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Synfacts 2021; 17(05): 0587
DOI: 10.1055/s-0040-1706184
DOI: 10.1055/s-0040-1706184
Peptide Chemistry
Thiopyridone-Derived Reagents for Peptide Coupling Reactions
Bailén MA,
Chinchilla R,
Dodsworth DJ,
Nájera C.
*
Universidad de Alicante, Spain
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q.
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q.
Significance
Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Nájera and co-workers reported a method for synthesizing thiopyridone-derived uronium salts as coupling reagents. The reagents were prepared from cheap starting materials, making them more economical than conventional coupling reagents such as HOBt.
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Comment
By using the thiopyridone-derived reagents as coupling reagents, various dipeptides were synthesized in moderate to excellent yields.
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Publication History
Article published online:
20 April 2021
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