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Synfacts 2021; 17(06): 0713
DOI: 10.1055/s-0040-1706210
DOI: 10.1055/s-0040-1706210
Peptide Chemistry
Phosphate-Reagent-Mediated Peptide Coupling Reactions
Li H,
Jiang X,
Ye Y.-H,
Fan C,
Romoff T,
Goodman M.
*
University of California at San Diego, USA and Peking University, Beijing, P. R. of China
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT): A New Coupling Reagent with Remarkable Resistance to Racemization.
Org. Lett. 1999;
1: 91-93
DOI: 10.1021/ol990573k.
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT): A New Coupling Reagent with Remarkable Resistance to Racemization.
Org. Lett. 1999;
1: 91-93
DOI: 10.1021/ol990573k.
Significance
Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Goodman and co-workers reported the development of the phosphate reagent 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) as a coupling reagent that can be easily prepared from diethyl chloridophosphate and 3-hydroxy-1,2,3-benzotriazin-4(3H)-one.
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Comment
By using DEPBT as a coupling reagent, various peptides can be synthesized in excellent yields.
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Publication History
Article published online:
18 May 2021
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