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Synfacts 2021; 17(07): 0825
DOI: 10.1055/s-0040-1706227
DOI: 10.1055/s-0040-1706227
Peptide Chemistry
Palladium-Catalyzed Olefination of Oxazole-Containing Peptides
Liu S,
Cai C,
Bai Z,
Sheng W,
Tan J,
*,
Wang H.
*
Chongqing Normal University and Nanjing University, P. R. of China
Late-Stage Macrocyclization of Bioactive Peptides with Internal Oxazole Motifs via Palladium-Catalyzed C–H Olefination.
Org. Lett. 2021;
23: 2933-2937
DOI: 10.1021/acs.orglett.1c00580.
Late-Stage Macrocyclization of Bioactive Peptides with Internal Oxazole Motifs via Palladium-Catalyzed C–H Olefination.
Org. Lett. 2021;
23: 2933-2937
DOI: 10.1021/acs.orglett.1c00580.
Significance
Late-stage functionalization of peptides has enormous potential for drug discovery. The authors have developed a palladium-catalyzed C(sp2)–H olefination at the aromatic ring of oxazole-containing peptides.
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Comment
The palladium-catalyzed olefination proceeds for various oxazolone-containing peptides. Moreover, this method can be applied to macrocyclization.
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Publication History
Article published online:
17 June 2021
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