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Total Synthesis of (±)-Ginkgolide B
Ginkgolide B is a diterpenoid isolated from Ginkgo biloba. The structural complexity and the biological properties of this natural product have fascinated chemists for decades.
Zinc homoenolate conjugate addition to A followed by cyclization yielded enone C. Conformational analysis led the authors to the discovery of a high-yielding photocycloaddition. Oxidative fragmentation and furan installation granted access to this intriguing molecule.
20 October 2020 (online)
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