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α-Arylation of Nitriles Catalyzed by Palladium Nanoparticles in Proline-Based Micelles
Scalable α-Arylation of Nitriles in Aqueous Micelles Using Ultrasmall Pd Nanoparticles: Surprising Formation of Carbanions in Water.
ACS Catal. 2020;
Palladium nanoparticles in micelles of a proline-based amphiphile ([email protected]), generated in situ (eq. 1), promoted the α-arylation of arylacetonitriles with aryl bromides to give the corresponding α-arylated products in up to 92% yield (eq. 2).
The PdNPs were characterized by means of 31P NMR, HRTEM, and EDAX analyses. A heterogeneous and amphiphilic vesicular Pd catalyst has been previously reported (see, for example: G. Hamasaka, T. Muto, Y. Uozumi Angew. Chem. Int. Ed. 2011, 50, 4876).
18 August 2020 (online)
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