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Copper-Catalyzed Synthesis of Nonnatural α-Amino Acids
Amino Acid Schiff Base Bearing Benzophenone Imine as a Platform for Highly Congested Unnatural α-Amino Acid Synthesis.
J. Am. Chem. Soc. 2020;
21 July 2020 (online)
Key wordsSchiff bases - nonnatural amino acids - benzophenone imines - alkylation - copper catalysis - asymmetric catalysis
Nonnatural amino acids are invaluable building blocks in synthetic organic chemistry. The authors have developed a copper-catalyzed approach for the synthesis of nonnatural α-amino acids.
This copper-catalyzed α-alkylation reaction provides the desired α-tetrasubstituted α-amino acids in moderate to high yields. The approach can be applied to a diastereoselective synthesis of α-tetrasubstituted α-amino acids by using a chiral auxiliary.