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Synfacts 2020; 16(08): 0991
DOI: 10.1055/s-0040-1707337
DOI: 10.1055/s-0040-1707337
Peptide Chemistry
Copper-Catalyzed Synthesis of Nonnatural α-Amino Acids
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Juli 2020 (online)
Key words
Schiff bases - nonnatural amino acids - benzophenone imines - alkylation - copper catalysis - asymmetric catalysisSignificance
Nonnatural amino acids are invaluable building blocks in synthetic organic chemistry. The authors have developed a copper-catalyzed approach for the synthesis of nonnatural α-amino acids.
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Comment
This copper-catalyzed α-alkylation reaction provides the desired α-tetrasubstituted α-amino acids in moderate to high yields. The approach can be applied to a diastereoselective synthesis of α-tetrasubstituted α-amino acids by using a chiral auxiliary.
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