Muramatsu W.
*
Hattori T,
Yamamoto H.
* Chubu University, Kasugai, Japan
Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis.
J. Am. Chem. Soc. 2019;
141: 12288-12295
Key words
tantalum catalysis - titanium catalysis - substrate-directed reaction
Significance
The development of elegant synthetic methodologies for peptide-bond formation is a
highly demanding task in organic synthesis. A substrate-directed, Lewis acid-catalyzed,
racemization-free amidation method has been developed to access various peptides.
Comment
The tantalum-catalyzed substrate-directed peptide-bond-formation reaction proceeds
with various amino acids under solvent-free conditions and delivers peptides in high
yields without racemization. This method further extends titanium-catalyzed oligopeptide
synthesis.
