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Journal of Pediatric Neurology 2021; 19(02): 127-131
DOI: 10.1055/s-0040-1716345
Case Report

Anti-MOG Antibody Syndrome and Cerebral Sinovenous Thrombosis: A Cause–Effect Hypothesis

Alessandra Fontana
1   Department of Clinical and Experimental Medicine, Postgraduate Training Program in Pediatrics, University of Catania, Catania, Italy
,
Filippo Greco
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
,
Pierluigi Smilari
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
,
Andrea D. Praticò
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
,
Agata Fiumara
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
,
Martino Ruggieri
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
,
Piero Pavone 
2   Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy
› Author Affiliations Funding None.
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Abstract

Cerebral venous thrombosis is an uncommon event of stroke in childhood. Its origin is multifactorial and often it manifests with nonspecific symptoms that may overlap with underlying predisposing factors. Anti–myelin oligodendrocyte glycoprotein (MOG) antibody syndrome is a group of recently recognized acquired demyelinating diseases that occur more commonly in children, usually, with a favorable outcome. The association between cerebral venous thrombosis and demyelinating syndrome has been reported but their clinical relationship is matter of debate and various hypotheses have been advanced including intravenous (IV) steroid therapy and/or the consequence of a shared inflammatory-thrombotic process. Herein, we report the case of a child with anti-MOG antibody syndromes who developed a thrombosis of the superior sagittal sinus and of the right Trolard's vein.

Keywords

anti-MOG antibody - cerebral sinovenous thrombosis - visual impairment - pseudotumor cerebri - lumbar puncture

Authors' Contributions

A.F., P.S., F.G., A. F., P.P., and A.D.P. reviewed the literature, critically discussed various aspects of epilepsy in pediatric patients, and read the manuscript.




Publication History

Received: 25 May 2020

Accepted: 25 July 2020

Article published online:
07 September 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Dlamini N, Billinghurst L, Kirkham FJ. Cerebral venous sinus (sinovenous) thrombosis in children. Neurosurg Clin N Am 2010; 21 (03) 511-527
    CrossrefPubMedGoogle Scholar
  • 2 Zhao T, Wang G, Dai J, Liu Y, Wang Y, Li S. Cases of visual impairment caused by cerebral venous sinus occlusion-induced intracranial hypertension in the absence of headache. BMC Neurol 2018; 18 (01) 159
    CrossrefPubMedGoogle Scholar
  • 3 Chitnis T. Pediatric central nervous system demyelinating diseases. Continuum (Minneap Minn) 2019; 25 (03) 793-814
    PubMedGoogle Scholar
  • 4 Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol 2019; 15 (02) 89-102
    CrossrefPubMedGoogle Scholar
  • 5 Serguera C, Stimmer L, Fovet CM. et al. Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases. J Neuroinflammation 2019; 16 (01) 244
    CrossrefPubMedGoogle Scholar
  • 6 Koudriavtseva T, Renna R, Plantone D, Mainero C. Demyelinating and thrombotic diseases of the central nervous system: common pathogenic and triggering factors. Front Neurol 2015; 6: 63
    CrossrefPubMedGoogle Scholar
  • 7 Soto-Insuga V, Salvador TA, Martinez LC. et al. Anti-myelin oligodendrocyte glycoprotein autoantibodies in optic neuritis and venous sinus thrombosis in a girl. J Pediatr Neurol and Med 2016; 1: 109
    CrossrefPubMedGoogle Scholar
  • 8 Jarius S, Ruprecht K, Kleiter I. et al; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016; 13 (01) 280
    CrossrefPubMedGoogle Scholar
  • 9 Vandenberghe N, Debouverie M, Anxionnat R, Clavelou P, Bouly S, Weber M. Cerebral venous thrombosis in four patients with multiple sclerosis. Eur J Neurol 2003; 10 (01) 63-66
    CrossrefPubMedGoogle Scholar
  • 10 van Zaane B, Nur E, Squizzato A. et al. Systematic review on the effect of glucocorticoid use on procoagulant, anti-coagulant and fibrinolytic factors. J Thromb Haemost 2010; 8 (11) 2483-2493
    CrossrefPubMedGoogle Scholar
  • 11 Cakmak S, Derex L, Berruyer M. et al. Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors. Neurology 2003; 60 (07) 1175-1178
    CrossrefPubMedGoogle Scholar
  • 12 Stokes S, Breheny P, Radulescu A, Radulescu VC. Impact of obesity on the risk of venous thromboembolism in an inpatient pediatric population. Pediatr Hematol Oncol 2014; 31 (05) 475-480
    CrossrefPubMedGoogle Scholar
  • 13 Friedman DI, Liu GT, Digre KB. Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology 2013; 81 (13) 1159-1165
    CrossrefPubMedGoogle Scholar
  • 14 Giacomini T, Foiadelli T, Annovazzi P. et al. Pediatric optic neuritis and anti MOG antibodies: a cohort of Italian patients. Mult Scler Relat Disord 2019; 39: 101917
    CrossrefPubMedGoogle Scholar
  • 15 Fernandez-Carbonell C, Vargas-Lowy D, Musallam A. et al. Clinical and MRI phenotype of children with MOG antibodies. Mult Scler 2016; 22 (02) 174-184
    CrossrefPubMedGoogle Scholar