Synlett 2022; 33(05): 429-439
DOI: 10.1055/s-0040-1719840
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Group-Selective Approaches to Complex Natural Product Synthesis: Three Examples of Diastereotopos-Selective Reactions

Ken Ohmori
,
This work was supported by Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP23000006, JP16H06351, JP16H01137, and JP16H04107).


Dedicated to Profs. Masaji Ohno, Susumu Kobayashi and Reinhard W. Hoffmann

Abstract

This Account showcases three diastereotopos-selective reactions exploited in our complex natural syntheses.

1 Introduction

2 Malyngolide: Hydroalumination of Bisalkynyl tert-Alcohols

3 Cavicularin: Acetal Cleavage

4 Carthamin: Bromoacetoxylation

5 Conclusions



Publication History

Received: 30 August 2021

Accepted after revision: 08 September 2021

Article published online:
13 October 2021

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