Synfacts 2021; 17(03): 0291
DOI: 10.1055/s-0040-1720317
Metals in Synthesis

Redox-Neutral Manganese-Catalyzed Silylation of Alkenes

Mark Lautens
Randy Sanichar
Dong J, Yuan X.-A, Yan Z, Mu L, Ma J, Zhu C, Xie J. * Nanjing University, P. R. of China
Manganese-Catalysed Divergent Silylation of Alkenes.

Nat. Chem. 2021;
13: 182-190
DOI: 10.1038/s41557-020-00589-8.


Xie and co-workers report a ­manganese-catalyzed dehydrosilylation and hydrosilylation of alkenes. They have shown that the reaction is easily scalable and affords the silylated product in good yields. The reaction proceeds equally well with both aliphatic and aromatic alkene starting materials.



Notably, the reaction is highly selective for the linear silylated product, stemming from the anti-Markovnikov addition of the silyl radical to the alkene. Additionally, under the specific conditions, either the dehydrosilylation or hydrosilylation product can be accessed with excellent selectivity.


Publication History

Publication Date:
16 February 2021 (online)

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