When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation

Abstract

Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.

Keywords

chronic inflammation - malignant degeneration - Marjolin's ulcer - BI-ALCL - radiation-induced sarcoma - Kaposi's sarcoma

Publication History

Article published online:
06 July 2021

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