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Synfacts 2022; 18(01): 0109
DOI: 10.1055/s-0041-1737497
DOI: 10.1055/s-0041-1737497
Peptide Chemistry
N-Propyl-1H-pyrazole-1-carboximidamide for the Synthesis of N ω-Propylarginine-Containing Dipeptides
Lee Y,
Silverman RB.
*
Northwestern University, Evanston, USA
Solid-Phase Syntheses of N ω-Propylarginine-Containing Dipeptides, Dipeptide Esters, and Dipeptide Amides.
Synthesis 1999; 1495-1499
DOI: 10.1055/s-1999-6077
Solid-Phase Syntheses of N ω-Propylarginine-Containing Dipeptides, Dipeptide Esters, and Dipeptide Amides.
Synthesis 1999; 1495-1499
DOI: 10.1055/s-1999-6077
Key words
solid-phase synthesis - arginine - propylpyrazolecarboxamidine - guanylating agent - dipeptides
Significance
N ω-Substituted arginine-containing peptides have a significant role in the endogenous synthesis of nitric oxide (NO). In 1999, Lee and Silverman developed an efficient method for the solid-phase synthesis of N ω-propylarginine-containing dipeptides.
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Comment
N-Propyl-1H-pyrazole-1-carboxamidine is an efficient guanylating agent for the synthesis of N ω-propylarginine-containing dipeptides in moderate yields. The method can be used for the synthesis of peptides having an N ω-propylarginine at either the N- or the C-terminus.
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Publication History
Article published online:
17 December 2021
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