Wu F.-P,
Yang Y,
Fuentes DP,
Wu X.-F.
*
Leibniz-Institut für Katalyse e.V., Rostock, Germany and Dalian Institute of Chemical
Physics, Liaoning, P. R. of China
Copper-Catalyzed Carbonylative Catenation of Olefins: Direct Synthesis of γ-Boryl
Esters.
Chem 2022;
DOI:
10.1016/j.chempr.2022.03.013
Key words
γ-boryl esters - boration - carbonylative catenation - copper catalysis - styrenes
Significance
A copper-catalyzed carbonylative four-component coupling of olefins to access γ-boryl
esters is disclosed. Two CO molecules act as the –CH2CO– source. The regio- and syn-selective boryl cupration gives the products in high stereoselectivity.
Comment
Based on 13C and 2H NMR labeling experiments, the shown mechanism is proposed. Further synthetic transformations
of the γ-boryl esters were performed to demonstrate the synthetic utility of this
protocol.
