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DOI: 10.1055/s-0041-1737670
A Novel Reagent for Coupling of Amino Acid Chlorides with Amino Acid Esters
1-(t-Butyldimethylsilyloxy) Benzotriazole (TBDMS-OBt): A New and Novel Reagent for the Synthesis of Peptides.
Lett. Peptide Sci.. 2002;
09: 35-41
DOI: 10.1023/A:1021307501833
Significance
The development of novel and efficient coupling reagents for peptide-bond formation is a continuous and highly demanding area in peptide chemistry. In 2002, Tantry and Babu reported that 1-{[tert-butyl(dimethyl)silyl]oxy}benzotriazole (TBDMS-OBt) is an efficient coupling reagent for the synthesis of dipeptides from amino acid chlorides and amino acid esters.
Comment
TBDMS-OBt is an efficient coupling reagent for the coupling of Fmoc-amino acid chlorides with amino acid esters to produce a series of dipeptides in good yields. This reaction is also successful with N-methyl amino acid esters. The coupling reation is racemization free and the TBDMS-OBt coupling reagent can be synthesized in one step.
Publikationsverlauf
Artikel online veröffentlicht:
15. Juni 2022
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