Abstract
Objective We sought to characterize the incidence and risk factors associated with developing
maternal morbidity following preterm prelabor rupture of membranes.
Study Design Retrospective case–control study of patients with preterm prelabor rupture of membranes
at a single institution from 2013 to 2019 admitted at ≥23 weeks gestational age. The
primary outcome was a composite of maternal morbidity which included: death, sepsis,
intensive care unit (ICU) admission, acute kidney injury, postpartum dilation and
curettage, postpartum hysterectomy, venous thromboembolism, postpartum hemorrhage,
postpartum wound complication, postpartum endometritis, pelvic abscess, postpartum
pneumonia, readmission, and/or need for blood transfusion were compared with patients
without above morbidities. Severe morbidity was defined as: death, ICU admission,
venous thromboembolism, acute kidney injury, postpartum hysterectomy, sepsis, and/or
transfusion >2 units. Demographics, antenatal, and delivery characteristics were compared
between patients with and without maternal morbidity. Bivariate statistics and regression
models were used to compare outcomes and calculate adjusted odd ratios.
Results Of 361 included patients, 64 patients (17.7%) experienced maternal morbidity and
nine (2.5%) had severe morbidity. Patients who experienced maternal morbidity were
significantly (p < 0.05) more likely to be older, have private insurance, have BMI ≥40, have chorioamnionitis
at delivery, and undergo cesarean or operative vaginal delivery when compared with
patients who did not experience morbidity. After controlling for confounders, cesarean
delivery (aOR 2.38, 95% CI[1.30,4.39]), body mass index ≥40 at admission (aOR 2.54,
95% CI[1.12,5.79]), private insurance (aOR 3.08, 95% CI[1.54,6.16]), and tobacco use
(aOR 3.43, 95% CI[1.58,7.48]) were associated with increased odds of maternal morbidity.
Conclusion In this cohort, maternal morbidity occurred in 17.7% of patients with preterm prelabor
rupture of membranes. Private insurance, body mass index ≥40, tobacco use, and cesarean
delivery were associated with higher odds of morbidity. These data can be used in
counseling and to advocate for smoking cessation.
Key Points
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17.7% of patients with PPROM experienced maternal morbidity.
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BMI ≥40 was associated with higher odds of maternal morbidity.
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Tobacco use and cesarean delivery were associated with higher odds of maternal morbidity.
Keywords
maternal morbidity - PPROM - tobacco use - preterm - cesarean delivery
