Z Orthop Unfall 2016; 154(02): 199-216
DOI: 10.1055/s-0042-102780
Refresher Orthopädie und Unfallchirurgie
Georg Thieme Verlag KG Stuttgart · New York

Osteochondrosis dissecans tali – eine kritische Übersicht

Osteochondritis Dissecans of the Talus – A Critical Review
J. Bruns
1   Klinik für Chirurgie und Orthopädie, Wilhemsburger Krankenhaus Groß-Sand, Hamburg
,
C. R. Habermann
2   Klinik für diagnostische und interventionelle Radiologie, Marienkrankenhaus Hamburg
,
J. P. Petersen
3   Zentrumfür Operative Medizin, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Hamburg-Eppendorf
› Author Affiliations
Further Information

Publication History

Publication Date:
05 December 2016 (online)

Zusammenfassung

Die Osteochondrosis dissecans (OD) tritt in Europa nach dem Kniegelenk am Sprunggelenk am zweithäufigsten auf. Ihre Ätiologie ist weiterhin nicht eindeutig geklärt. Es werden verschiedene Faktoren diskutiert. Am wahrscheinlichsten ist eine traumatische oder repetitive mikrotraumatische Genese. Die Pathogenese ist relativ eindeutig: Die Läsion beginnt im subchondralen Knochen, erst sekundär wird der über der knöchernen Läsion liegende Knorpel mit betroffen und kann zur Bildung eines freien Gelenkkörpers führen. Diagnostisch stellt die Erstellung eines Röntgenbilds des oberen Sprunggelenks in 2 Ebenen die erste Maßnahme dar. Das MRT gilt heute als Methode der Wahl zur erweiterten Diagnostik. Therapeutisch gibt es auf der konservativen Seite keine einheitlichen Protokolle. Die Reduktion der Last mit oder ohne Immobilisation des oberen Sprunggelenks und/oder Sportkarenz sind die wesentlichen Maßnahmen. Bei erfolgloser konservativer Therapie und bei fortgeschrittenen Läsionen kommen verschiedene operative Behandlungsmöglichkeiten infrage. Bei intaktem Knorpel werden verschiedene Techniken der Anbohrung der subchondralen Läsion verwendet. Bei lädiertem Knorpel gibt es Methoden zur Refixation, Rekonstruktion oder Maßnahmen, die den Knorpel-Knochen-Defekt lediglich débridieren und den subchondralen Knochen anbohren. Leider existiert bis heute nur eine Level-I-Untersuchung, in der nicht nur Fälle von Osteochondrosis dissecans tali, sondern auch von osteochondralen Läsionen des Talus gemeinsam untersucht wurden. In dieser Arbeit zeigte der Vergleich zwischen einer Chondroplastik und einer Mikrofrakturierung keine wesentlichen Unterschiede, Patienten mit einer osteochondralen Transplantation wiesen dagegen signifikant bessere Ergebnisse auf. Langfristig ist nur eine geringe Arthrose zu erwarten.

Abstract

The etiology remains unclear. Mechanical factors seem to play an important role. Most histologies report clefts between the cartilage and bone and necrotic areas. Several classifications have been published based on observations from imaging techniques or on intraoperative findings. Clinical symptoms are unspecific. Imaging techniques are of great importance: X-rays of the ankle joint enable a quick diagnostic overview. MRT is the imaging-technique of choice for diagnosing OCDT-lesions. Regarding treatment, a tremendous number of retrospective publications exist. Only a few are classified as level I or II papers. Patients with open physes and low-grade lesions have good results with conservative therapy. Adults do not profit from a longer conservative procedure. Where surgery is necessary, the procedure depends on the stage of the lesion and on the state of the cartilage. With intact cartilage, retrograde procedures or transchondral drilling are to be favoured. Where the cartilage is damaged, several techniques can be used: while techniques such as drilling and microfracturing, or matrix-associated microfracturing produces repair cartilage, other techniques reconstruct the defect with osteochondral grafts or cell-based procedures such as chondrocyte transplantation. Regarding the outcome, it is difficult to make a precise, scientifically-based recommendation which has been confirmed by more than one prospective study. Only limited recommendations are possible: In juveniles with intact cartilage, initially conservative treatment is indicated. If there is no improvement, conservative invasive techniques such as drilling may help. In adults conservative therapy should be limited to a few weeks. Regarding the surgical treatment options, there is a tendency towards better results with procedures which reconstruct the bone and the cartilage and there is also a trend towards better long-term results when co-morbidities are treated. Severe grades of osteoarthrosis are rare.

Literaturverzeichnis als PDF

 
  • Literatur

  • 1 Green W, Banks HH. Osteochondritis dissecans in children. J Bone Joint Surg Am 1953; 35-A: 26-47
  • 2 König F. Ueber freie Körper in den Gelenken. Dtsch Z Chir 1888; 27: 90-109
  • 3 Freiberg A, Woolley PG. Osteochondritis dissecans: concerning its nature and relation to formation of joint mice. J Bone Joint Surg Am 1910; s2–s8: 477-494
  • 4 Kappis M. Weitere Beiträge zur traumatisch-mechanischen Entstehung der „spontanen“ Knorpelablösungen (sogen. Osteochondritis dissecans). Dt Zeitschr Chir 1922; 154: 13-29
  • 5 Smillie I ed. Osteochondritis dissecans. Loose Bodies in Joints. Edinburgh, London: E.S. Livingstone; 1960
  • 6 Mubarak SJ, Carroll NC. Familial osteochondritis dissecans of the knee. Clin Orthop Relat Res 1979; 140: 131-136
  • 7 Cahill BR. Osteochondritis dissecans of the knee: Treatment of juvenile and adult forms. J Am Acad Orthop Surg 1995; 3: 237-247
  • 8 Hefti F, Beguiristain J, Krauspe R et al. Osteochondritis dissecans: a multicenter study of the European Pediatric Orthopedic Society. J Pediatr Orthop B 1999; 8: 231-245
  • 9 Bauer R. Ein Beitrag zu den aseptischen Knochennekrosen im Bereich des Ellbogengelenkes. Arch Orthop Unfallchir 1968; 64: 379-387
  • 10 Bauer M, Jonsson K, Josefsson P et al. Osteochondritis dissecans of the elbow. A long-term follow-up study. Clin Orthop Relat Res 1992; 284: 156-160
  • 11 Thompson J, Loomer RL. Osteochondral lesions of the talus in a sports medicine clinic. A new radiographic technique and surgical approach. Am J Sports Med 1984; 12: 460-463
  • 12 Kessler J, Weiss JM, Nikizad H et al. Osteochondritis dissecans of the ankle in children and adolescents: demographics and epidemiology. Am J Sports Med 2014; 42: 320-326
  • 13 Federico DJ, Lynch JK, Jokl P. Osteochondritis dissecans of the knee: a historical review of etiology and treatment. Arthroscopy 1990; 6: 190-197
  • 14 Gelberman R, Mortensen WW. The arterial anatomy of the talus. Foot Ankle 1983; 4: 64-72
  • 15 Miller A, Prasarn ML, Dyke JP et al. Quantitative assessment of the vascularity of the talus with gadolinium-enhanced magnetic resonance imaging. J Bone Joint Surg Am 2011; 93: 1116-1121
  • 16 Imhof H, Sulzbacher I, Grampp S et al. Subchondral bone and cartilage disease: a rediscovered functional unit. Invest Radiol 2000; 35: 581-588
  • 17 Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc 2010; 18: 419-433
  • 18 Andrew T, Spivey J, Lindebaum RH. Familial osteochondritis dissecans and dwarfism. Acta Orthop Scand 1981; 52: 519-523
  • 19 Kozlowski K, Middleton R. Familial osteochondritis dissecans: a dysplasia of articular cartilage?. Skeletal Radiol 1985; 13: 207-210
  • 20 Phillips H, Grubb SA. Familial multiple osteochondritis dissecans. Report of a kindred. J Bone Joint Surg Am 1985; 67: 155-156
  • 21 Paes R. Familial osteochondritis dissecans. Clin Radiol 1989; 40: 501-504
  • 22 Petrie PW. Aetiology of osteochondrosis dissecans. Failure to establish a familial background. J Bone Joint Surg Br 1977; 59-B: 366-367
  • 23 Stattin EL, Wiklund F, Lindblom K et al. A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans. Am J Hum Genet 2010; 86: 126-137
  • 24 Aspberg A. The different roles of aggrecan interaction domains. J Histochem Cytochem 2012; 987-996
  • 25 Stattin EL, Tegner Y, Domellöf M et al. Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature. Osteoarthritis Cartilage 2008; 16: 890-896
  • 26 Aurich M, Hofmann GO, Mückley T et al. In vitro phenotypic modulation of chondrocytes from knees of patients with ostechondritis dissecans: implications for chondrocyte implantation procedures. J Bone Joint Surg Br 2012; 94: 62-67
  • 27 Clark J, Huber JD. The structure of the human subchondral plate. J Bone Joint Surg Br 1990; 72: 866-873
  • 28 Ribbing S. Studien über hereditäre, multiple Epiphysenstörungen. Acta Radiol 1937; 34 (Suppl.) 1-107
  • 29 Ribbing S. The hereditary multiple epiphyseal disturbance and its consequences for the aetiogenesis of local malacias-particularly the osteochondrosis dissecans. Acta Orthop Scand 1955; 24: 286-299
  • 30 Jans L, Jaremko JL, Ditchfield M et al. MRI differentiates femoral condylar ossification evolution from osteochondritis dissecans. A new sign. Eur Radiol 2011; 21: 1170-1179
  • 31 Jans L, Jaremko J, Ditchfield M et al. Ossification variants of the femoral condyles are not associated with osteochondritis dissecans. Eur J Radiol 2012; 81: 3384-3389
  • 32 Zwingmann J, Südkamp NP, Schmal H et al. Surgical treatment of osteochondritis dissecans of the talus: a systematic review. Arch Orthop Trauma Surg 2012; 132: 1241-1250
  • 33 Berndt AL, Harty M. Transchondral fractures (osteochondritis dissecans) of the talus. J Bone Joint Surg Am 1959; 41-A: 988-1020
  • 34 McCullough C, Venugopal V. Osteochondritis dissecans of the talus: the natural history. Clin Orthop Relat Res 1979; 144: 264-268
  • 35 Alexander A, Lichtman DM. Surgical treatment of transchondral talar dome fractures (osteochondritis dissecans). Long-term follow-up. J Bone Joint Surg Am 1980; 62: 646-652
  • 36 Naumetz V, Schweigel JF. Osteocartilagenous lesions of the talar dome. J Trauma 1980; 20: 924-927
  • 37 Flick AB, Gould N. Osteochondritis dissecans of the talus (transchondral fractures of the talus): review of the literature and new surgical approach for medial dome lesions. Foot Ankle 1985; 5: 165-185
  • 38 Parisien JS. Arthroscopic treatment of osteochondral lesions of the talus. Am J Sports Med 1986; 14: 211-217
  • 39 van Dijk C, Reilingh ML, Zengerink M et al. Osteochondral defects in the ankle: why painful?. Knee Surg Sports Traumatol Arthrosc 2010; 18: 570-580
  • 40 Haene R, Qamirani E, Story RA et al. Intermediate outcomes of fresh talar osteochondral allografts for treatment of large osteochondral lesions of the talus. J Bone Joint Surg Am 2012; 94: 1105-1110
  • 41 Bruns J, Rosenbach B. Pressure distribution at the ankle joint. Clin Biomech 1990; 5: 153-161
  • 42 Krause F, Blatter S, Waehnert D et al. Hindfoot joint pressure in supination sprains. Am J Sports Med 2012; 40: 902-908
  • 43 Ramsey P, Hamilton W. Changes in tibiotalar area of contact caused by lateral talar shift. J Bone Joint Surg Am 1976; 58: 356-357
  • 44 Elias I, Zoga AC, Morrison WB et al. Osteochondral lesions of the talus: localization and morphologic data from 424 patients using a novel anatomical grid scheme. Foot Ankle Int 2007; 28: 154-161
  • 45 Verhagen RA, Struijs PA, Bossuyt PM et al. Systematic review of treatment strategies for osteochondral defects of the talar dome. Foot Ankle Clin 2003; 8: 233-242
  • 46 Orr JD, Dutton JR, Fowler JT. Anatomic location and morphology of symptomatic, operatively treated osteochondral lesions of the talus. Foot Ankle Int 2012; 33: 1051-1057
  • 47 Radin E, Paul IL. Does cartilage compliance reduce skeletal impact loads? The relative force-attenuating properties of articular cartilage, synovial fluid, periarticular soft tissues and bone. Arthritis Rheum 1970; 13: 139-144
  • 48 Radin EL, Paul IL, Lowy M. A comparison of the dynamic force transmitting properties of subchondral bone and articular cartilage. J Bone Joint Surg Am 1970; 52: 444-456
  • 49 Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986; 213: 34-40
  • 50 Brown TD, Vrahas MS. The apparent elastic modulus of the juxtarticular subchondral bone of the femoral head. J Orthop Res 1984; 2: 32-38
  • 51 Procter P, Paul JP. Ankle joint biomechanics. J Biomech 1982; 15: 627-634
  • 52 Mow V, Flatow EL, Ateshian GA. Biomechanics. In: Buckwalter JA, Einhorn TA, Shelton RS, eds. Orthopaedic basic Science: Biology and Biomechanics of the musculoskeletal System. 2nd ed. Rosemont: American Academy of Orthopaedic Surgeons; 2000: 133-180
  • 53 Gruber K, Ruder H, Denoth J et al. A comparative study of impact dynamics: wobbling mass model versus rigid body models. J Biomech 1998; 31: 439-444
  • 54 Athanasiou KA, Niederauer GG, Schenck jr. RC. Biomechanical topography of human ankle cartilage. Ann Biomed Eng 1995; 23: 697-704
  • 55 Simon WH, Friedenberg S, Richardson S. Joint congruence. A correlation of joint congruence and thickness of articular cartilage in dogs. J Bone Joint Surg Am 1973; 55: 1614-1620
  • 56 Shepherd DE, Seedhom BB. Thickness of human articular cartilage in joints of the lower limb. Ann Rheum Dis 1999; 58: 27-34
  • 57 Bruns J. Osteochondrosis dissecans. Stuttgart: Enke; 1996
  • 58 Bruns J, Werner M, Soyka M. Is vitamin D insufficiency or deficiency related to the development of osteochondritis dissecans?. Knee Surg Sports Traumatol Arthrosc 2014; DOI: 10.1007/s00167-014-3413-7.
  • 59 Aichroth P. Osteochondritis dissecans of the knee. A clinical survey. J Bone Joint Surg Br 1971; 53: 440-447
  • 60 Arcq M. Behandlung der Osteochondrosis dissecans durch Knochenspanbolzung. Arch Orthop Unfallchir 1974; 79: 297-312
  • 61 Nishimura G, Yamato M, Togawa M. Trabecular trauma of the talus and medial malleolus concurrent with lateral collateral ligamentous injuries of the ankle: evaluation with MR imaging. Skeletal Radiol 1996; 25: 49-54
  • 62 McCollum G, Myerson MS, Jonck J. Managing the cystic osteochondral defect: allograft or autograft. Foot Ankle Clin 2013; 18: 113-133
  • 63 Krappel F, Bauer E, Harland U. Are bone bruises a possible cause of osteochondritis dissecans of the capitellum? A case report and review of the literature. Arch Orthop Trauma Surg 2005; 125: 545-549
  • 64 Crawford DC, Safran MR. Osteochondritis dissecans of the knee. J Am Acad Orthop Surg 2006; 14: 90-100
  • 65 Nakamae A, Engebretsen L, Bahr R et al. Natural history of bone bruises after acute knee injury: clinical outcome and histopathological findings. Knee Surg Sports Traumatol Arthrosc 2006; 14: 1252-1258
  • 66 Uozumi H, Sugita T, Aizawa T et al. Histologic findings and possible causes of osteochondritis dissecans of the knee. Am J Sports Med 2009; 37: 2003-2008
  • 67 Shea KG, Jacobs jr. JC, Grimm NL et al. Osteochondritis dissecans development after bone contusion of the knee in the skeletally immature: a case series. Knee Surg Sports Traumatol Arthrosc 2013; 21: 403-407
  • 68 Wagner H. Operative Behandlung der Osteochondrosis dissecans des Kniegelenkes. Z Orthop 1964; 98: 333-355
  • 69 Wagner H. Surgical treatment of osteochondritis dissecans, a cause of arthritis deformans of the knee. Rev Chir Orthop Reparat Apparat Mot 1964; 50: 335-352
  • 70 Garrett JC. Osteochondritis dissecans. Clin Sports Med 1991; 10: 569-593
  • 71 Kocher MS, Tucker R, Ganley TJ et al. Management of osteochondritis dissecans of the knee: current concepts review. Am J Sports Med 2006; 34: 1181-1191
  • 72 Rodegerdts U, Gleissner S. Langzeiterfahrungen mit der operativen Therapie der Osteochondrosis dissecans des Kniegelenkes. Orthop Prax 1979; 15: 612-622
  • 73 Guhl JF. Arthroscopic treatment of osteochondritis dissecans. Clin Orthop Relat Res 1982; 167: 65-74
  • 74 Cahill B, Berg BC. 99m-Technetium phosphate compound joint scintigraphy in the management of juvenile osteochondritis dissecans of the femoral condyles. Am J Sports Med 1983; 11: 329-335
  • 75 Hughston JC, Hergenroeder PT, Courtenay BG. Osteochondritis dissecans of the femoral condyles. J Bone Joint Surg Am 1984; 66: 1340-1348
  • 76 Ewing JW, Voto SJ. Arthroscopic surgical management of osteochondritis dissecans of the knee. Arthroscopy 1988; 4: 37-40
  • 77 Nelson DW, DiPaola J, Colville M et al. Osteochondritis dissecans of the talus and knee: prospective comparison of MR and arthroscopic classification. J Comput Assist Tomogr 1990; 14: 804-808
  • 78 Dipaola J, Nelson DW, Colville MR. Characterizing osteochondral lesions by magnetic resonance imaging. Arthroscopy 1991; 7: 101-104
  • 79 Kramer J, Stiglbauer R, Engel A et al. MR contrast arthrography (MRA) in osteochondrosis dissecans. J Comput Assist Tomogr 1992; 16: 254-260
  • 80 OʼConnor MA, Palaniappan M, Khan N et al. Osteochondritis dissecans of the knee in children. A comparison of MRI and arthroscopic findings. J Bone Joint Surg Br 2002; 84: 258-262
  • 81 Brittberg M, Winalski CS. Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 2003; 85-A (Suppl. 02) 58-69
  • 82 Hughes JA, Cook JV, Churchill MA et al. Juvenile osteochondritis dissecans: a 5-year review of the natural history using clinical and MRI evaluation. Pediatr Radiol 2003; 33: 410-417
  • 83 Cahill BR, Phillips MR, Navarro R. The results of conservative management of juvenile osteochondritis dissecans using joint scintigraphy. A prospective study. Am J Sports Med 1989; 17: 601-605 discussion 605–606
  • 84 Loomer R, Fisher C, Lloyd-Smith R et al. Osteochondral lesions of the talus. Am J Sports Med 1993; 21: 13-19
  • 85 De Smet AA, Ilahi OA, Graf BK. Untreated osteochondrosis dissecans of the femoral condyles: prediction of patient outcome using radiographic and MR findings. Skeletal Radiol 1997; 26: 463-467
  • 86 Takahara M, Mura N, Sasaki J et al. Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. J Bone Joint Surg Am 2007; 89: 1205-1214
  • 87 Takahara M, Mura N, Sasaki J et al. Classification, treatment, and outcome of osteochondritis dissecans of the humeral capitellum. Surgical technique. J Bone Joint Surg Am 2008; 90 (Suppl. 21) 47-62
  • 88 Edmonds E, Polousky J. A review of knowledge in osteochondritis dissecans: 123 years of minimal evolution from König to the ROCK study group. Clin Orthop Relat Res 2013; 471: 1118-1126
  • 89 Anders S, Goetz J, Schubert T et al. Treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation—results at five years. Int Orthop 2012; 36: 2279-2285
  • 90 Lee C, Chao KH, Huang GS et al. Osteochondral autografts for osteochondritis dissecans of the talus. Foot Ankle Int 2003; 24: 815-822
  • 91 Valderrabano V, Leumann A, Rasch H et al. Knee-to-ankle mosaicplasty for the treatment of osteochondral lesions of the ankle joint. Am J Sports Med 2009; 37 (Suppl. 01) 105S-111S
  • 92 Woelfle J, Reichel H, Nelitz M. Indications and limitations of osteochondral autologous transplantation in osteochondritis dissecans of the talus. Knee Surg Sports Traumatol Arthrosc 2013; 21: 1925-1930
  • 93 Woelfle JV, Reichel H, Javaheripour-Otto K et al. Clinical outcome and magnetic resonance imaging after osteochondral autologous transplantation in osteochondritis dissecans of the talus. Foot Ankle Int 2013; 34: 173-179
  • 94 Kitaoka H, Alexander IJ, Adelaar RS et al. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int 1994; 15: 349-353
  • 95 Sammarco GJ, Makwana NK. Treatment of talar osteochondral lesions using local osteochondral graft. Foot Ankle Int 2002; 23: 693-698
  • 96 Gobbi A, Francisco RA, Lubowitz JH et al. Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation. Arthroscopy 2006; 22: 1085-1092 Erratum in: Arthroscopy 2008; 24: A16 Erratum in: Arthroscopy 2008; 24: A16
  • 97 Giannini S, Battaglia M, Buda R et al. Surgical treatment of osteochondral lesions of the talus by open-field autologous chondrocyte implantation: a 10-year follow-up clinical and magnetic resonance imaging T2-mapping evaluation. Am J Sports Med 2009; 37 (Suppl. 01) 112S-118S
  • 98 Raikin SM. Fresh osteochondral allografts for large-volume cystic osteochondral defects of the talus. J Bone Joint Surg Am 2009; 91: 2818-2826
  • 99 Schneider T, Karaikudi S. Matrix-induced autologous chondrocyte implantation (MACI) grafting for osteochondral lesions of the talus. Foot Ankle Int 2009; 30: 810-814
  • 100 Becher C, Thermann H. Results of microfracture in the treatment of articular cartilage defects of the talus. Foot Ankle Int 2005; 26: 583-589
  • 101 Haasper C, Zelle BA, Knobloch K et al. No mid-term difference in mosaicplasty in previously treated versus previously untreated patients with osteochondral lesions of the talus. Arch Orthop Trauma Surg 2008; 128: 499-504
  • 102 Lahm A, Erggelet C, Steinwachs M et al. [Arthroscopic therapy of osteochondrosis dissecans of the talus—follow-up with a new “Ankle Score”]. Sportverletz Sportschaden 1998; 12: 107-113
  • 103 Ogilvie-Harris DJ, Sarossa EA. Arthroscopic treatment of osteochondritis dissecans of the talus. Arthroscopy 1999; 15: 805-808
  • 104 Schuman L, Struijs PA, van Dijk CN. Arthroscopic treatment for osteochondral defects of the talus. Results at follow-up at 2 to 11 years. J Bone Joint Surg Br 2002; 84: 364-368
  • 105 van Bergen CJ, Kox LS, Maas M et al. Arthroscopic treatment of osteochondral defects of the talus: outcomes at eight to twenty years of follow-up. J Bone Joint Surg Am 2013; 95: 519-525
  • 106 Lam KY, Siow HM. Conservative treatment for juvenile osteochondritis dissecans of the talus. J Orthop Surg (Hong Kong) 2012; 20: 176-180
  • 107 Hangody L, Kish G, Módis L et al. Mosaicplasty for the treatment of osteochondritis dissecans of the talus: two to seven year results in 36 patients. Foot Ankle Int 2001; 22: 552-558
  • 108 Hangody L. The mosaicplasty technique for osteochondral lesions of the talus. Foot Ankle Clin 2003; 8: 259-273
  • 109 Mintz D, Tashjian GS, Connell DA et al. Osteochondral lesions of the talus: a new magnetic resonance grading system with arthroscopic correlation. Arthroscopy 2003; 19: 353-359
  • 110 OʼLoughlin PF, Heyworth BE, Kennedy JG. Current concepts in the diagnosis and treatment of osteochondral lesions of the ankle. Am J Sports Med 2010; 38: 392-404
  • 111 Bruns J, Rosenbach B. Osteochondrosis dissecans of the talus. Arch Orthop Trauma Surg 1992; 112: 23-27
  • 112 Shearer C, Loomer R, Clement D. Nonoperatively managed stage 5 osteochondral talar lesions. Foot Ankle Int 2002; 23: 651-654
  • 113 Marlovits S, Singer P, Zeller P et al. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol 2006; 57: 16-23
  • 114 Clanton TO, DeLee JC. Osteochondritis dissecans. History, pathophysiology and current treatment concepts. Clin Orthop Relat Res 1982; 167: 50-64
  • 115 Green WT, Banks HH. Osteochondritis dissecans in children. Clin Orthop Relat Res 1990; 255: 3-12
  • 116 Barrie HJ. Hypertrophy and laminar calcification of cartilage in loose bodies as probable evidence of an ossification abnormality. J Pathol 1980; 132: 161-168
  • 117 Barrie HJ. Hypothesis—a diagram of the form and origin of loose bodies in osteochondritis dissecans. J Rheumatol 1984; 11: 512-513
  • 118 Chiroff RT, Cooke 3rd CP. Osteochondritis dissecans: a histologic and microradiographic analysis of surgically excised lesions. J Trauma 1975; 15: 689-696
  • 119 Koch S, Kampen WU, Laprell H. Cartilage and bone morphology in osteochondritis dissecans. Knee Surg Sports Traumatol Arthrosc 1997; 5: 42-45
  • 120 Aurich M, Anders J, Trommer T et al. Histological and cell biological characterization of dissected cartilage fragments in human osteochondritis dissecans of the femoral condyle. Arch Orthop Trauma Surg 2006; 126: 606-614
  • 121 Shea KG, Jacobs jr. JC, Carey JL et al. Osteochondritis dissecans knee histology studies have variable findings and theories of etiology. Clin Orthop Relat Res 2013; 471: 1127-1136
  • 122 Schenck jr. RC, Goodnight JM. Osteochondritis dissecans. J Bone Joint Surg Am 1996; 78: 439-456
  • 123 Preiss A, Heitmann M, Frosch KH. Operative Therapie bei Osteochondrosis dissecans des Talus. Innenknöchelosteotomie mit Kürettage, Spongiosaauffüllung und Refixation. Unfallchirurg 2012; 115: 1099-1108
  • 124 Ferkel R, Flannigan BD, Elkins BS. Magnetic resonance imaging of the foot and ankle: correlation of normal anatomy with pathologic conditions. Foot Ankle 1991; 11: 289-305
  • 125 Hepple S, Winson IG, Glew D. Osteochondral lesions of the talus: a revised classification. Foot Ankle Int 1999; 20: 789-793
  • 126 Chen CH, Liu YS, Choud PH et al. MR grading system of osteochondritis dissecans lesions: comparison with arthroscopy. Eur J Radiol 2013; 82: 518-525
  • 127 Saupe N, Pfirrmann CWA, Schmid MR et al. MR imaging of cartilage in cadaveric wrists: comparison between imaging at 1.5 and 3.0 T and gross pathologic inspection. Radiology 2007; 243: 180-187
  • 128 Bellelli A, Avitto A, David V. [Spontaneous remission of osteochondritis dissecans in 8 pediatric patients undergoing conservative treatment]. Radiol Med 2001; 102: 148-153
  • 129 Edelstein J. Osteochondritis dissecans with spontaneous healing. J Bone Joint Surg Br 1954; 36: 343
  • 130 Sales de Gauzy J, Mansat C, Darodes PH et al. Natural course of osteochondritis dissecans in children. J Pediatr Orthop B 1999; 8: 26-28
  • 131 Takahara M, Ogino T, Takagi M et al. Natural progression of osteochondritis dissecans of the humeral capitellum: initial observations. Radiology 2000; 216: 207-212
  • 132 Van Demark RE. Osteochondritis dissecans with spontaneous healing. J Bone Joint Surg Am 1952; 34: 143-148
  • 133 Baker C, Andrews JR, Ryan JB. Arthroscopic treatment of transchondral talar dome fractures. Arthroscopy 1986; 2: 82-87
  • 134 Pettine KA, Morrey BF. Osteochondral fractures of the talus. A long-term follow-up. J Bone Joint Surg Br 1987; 69: 89-92
  • 135 Pritsch M, Horoshovski H, Farine I. Arthroscopic treatment of osteochondral lesions of the talus. J Bone Joint Surg Am 1986; 68: 862-865
  • 136 Tol JL, Struijs PAA, Bossuyt PMM et al. Treatment strategies in osteochondral defects of the talar dome: a systematic review. Foot Ankle Int 2000; 21: 119-126
  • 137 Perumal V, Wall E, Babekir N. Juvenile osteochondritis dissecans of the talus. J Pediatr Orthop 2007; 27: 821-825
  • 138 Zengerink M, Struijs PA, Tol JL et al. Treatment of osteochondral lesions of the talus: a systematic review. Knee Surg Sports Traumatol Arthrosc 2010; 18: 238-246
  • 139 Higuera J, Laguna R, Peral M et al. Osteochondritis dissecans of the talus during childhood and adolescence. J Pediatr Orthop 1998; 18: 328-332
  • 140 Letts M, Davidson D, Ahmer A. Osteochondritis dissecans of the talus in children. J Pediatr Orthop 2003; 23: 617-625
  • 141 Struijs PA, Tol JL, Bossuyt PM et al. Behandlungsstrategien bei osteochondralen Läsionen des Talus. Literaturübersicht. Orthopäde 2001; 30: 28-36
  • 142 Kumai T, Takakura Y, Higashiyama I et al. Arthroscopic drilling for the treatment of osteochondral lesions of the talus. J Bone Joint Surg Am 1999; 81: 1229-1235
  • 143 Donnenwerth MP, Roukis TS. Outcome of arthroscopic debridement and microfracture as the primary treatment for osteochondral lesions of the talar dome. Arthroscopy 2012; 28: 1902-1907
  • 144 Greenspoon J, Rosman M. Medial osteochondritis of the talus in children: review and new surgical management. J Pediatr Orthop 1987; 7: 705-708
  • 145 Kolker D, Murray M, Wilson M. Osteochondral defects of the talus treated with autologous bone grafting. J Bone Joint Surg Br 2004; 86: 521-526
  • 146 Giannini S, Buda R, Grigolo B et al. Autologous chondrocyte transplantation in osteochondral lesions of the ankle joint. Foot Ankle Int 2001; 22: 513-517
  • 147 Giannini S, Vannini F, Buda R. Osteoarticular grafts in the treatment of OCD of the talus: mosaicplasty versus autologous chondrocyte transplantation. Foot Ankle Clin 2002; 7: 621-633
  • 148 Giannini S, Buda R, Faldini C et al. Surgical treatment of osteochondral lesions of the talus in young active patients. J Bone Joint Surg Am 2005; 87 (Suppl. 02) 28-41
  • 149 Giannini S, Buda R, Grigolo B et al. The detached osteochondral fragment as a source of cells for autologous chondrocyte implantation (ACI) in the ankle joint. Osteoarthritis Cartilage 2008; 13: 601-607
  • 150 Giannini S, Buda R, Vannini F et al. Arthroscopic autologous chondrocyte implantation in osteochondral lesions of the talus: surgical technique and results. Am J Sports Med 2008; 36: 873-880
  • 151 Valderrabano V, Miska M, Leumann A et al. Reconstruction of osteochondral lesions of the talus with autologous spongiosa grafts and autologous matrix-induced chondrogenesis. Am J Sports Med 2013; 41: 519-527
  • 152 Kwak SK, Kern BS, Ferkel RD et al. Autologous chondrocyte implantation of the ankle: 2- to 10-year results. Am J Sports Med 2014; 42: 2156-2164
  • 153 Kreulen C, Giza E, Kim J et al. Viability of talus osteochondral defect cartilage for chondrocyte harvesting: results of 151 patients. Foot Ankle Int 2014; 35: 341-345
  • 154 Buda R, Vannini F, Castagnini F et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation. Int Orthop 2015; 39: 893-900
  • 155 Emre TY, Ege T, Cift HT et al. Open mosaicplasty in osteochondral lesions of the talus: a prospective study. J Foot Ankle Surg 2012; 51: 556-560
  • 156 Scranton PJ, Frey CC, Feder KS. Outcome of osteochondral autograft transplantation for type-V cystic osteochondral lesions of the talus. J Bone Joint Surg Br 2006; 88: 614-619
  • 157 Schöttle PB, Oettl GM, Agneskirchner JD et al. Operative Therapie von osteochondralen Lasionen am Talus mit autologer Knorpel-Knochen-Transplantation. Orthopäde 2001; 30: 53-58
  • 158 Baltzer A, Arnold JP. Bone-cartilage transplantation from the ipsilateral knee for chondral lesions of the talus. Arthroscopy 2005; 21: 159-166
  • 159 Kreuz P, Steinwachs M, Erggelet C et al. Mosaicplasty with autogenous talar autograft for osteochondral lesions of the talus after failed primary arthroscopic management: a prospective study with a 4-year follow-up. Am J Sports Med 2006; 34: 55-63
  • 160 Choung D, Christensen JC. Mosaicplasty of the talus: a joint contact analysis in a cadaver model. J Foot Ankle Surg 2002; 41: 65-75
  • 161 Fansa AM, Murawski CD, Imhauser CW et al. Autologous osteochondral transplantation of the talus partially restores contact mechanics of the ankle joint. Am J Sports Med 2011; 39: 2457-2465
  • 162 Kreuz P, Lahm A, Haag M et al. Tibial wedge osteotomy for osteochondral transplantation in talar lesions. Int J Sports Med 2008; 29: 584-589
  • 163 Assenmacher J, Kelikian AS, Gottlob C et al. Arthroscopically assisted autologous osteochondral transplantation for osteochondral lesions of the talar dome: an MRI and clinical follow-up study. Foot Ankle Int 2001; 22: 544-551
  • 164 Gomoll A, Farr J, Gillogly SD et al. Surgical management of articular cartilage defects of the knee. J Bone Joint Surg Am 2010; 92: 2470-2490
  • 165 LaPrade R, Botker J, Herzog M et al. Refrigerated osteoarticular allografts to treat articular cartilage defects of the femoral condyles. A prospective outcomes study. J Bone Joint Surg Am 2009; 91: 805-811
  • 166 Williams SK, Amiel D, Ball ST et al. Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg Am 2003; 85-A: 2111-2120
  • 167 Pearsall 4th AW, Tucker JA, Hester RB et al. Chondrocyte viability in refrigerated osteochondral allografts used for transplantation within the knee. Am J Sports Med 2004; 32: 125-131
  • 168 Ball ST, Amiel D, Williams SK et al. The effects of storage on fresh human osteochondral allografts. Clin Orthop Relat Res 2004; 418: 246-252
  • 169 Mroz T, Joyce MJ, Steinmetz MP et al. Musculoskeletal allograft risks and recalls in the United States. J Am Acad Orthop Surg 2008; 16: 559-565
  • 170 Hahn DB, Aanstoos ME, Wilkins RM. Osteochondral lesions of the talus treated with fresh talar allografts. Foot Ankle Int 2010; 31: 277-282
  • 171 El-Rashidy H, Villacis D, Omar I et al. Fresh osteochondral allograft for the treatment of cartilage defects of the talus: a retrospective review. J Bone Joint Surg Am 2011; 93: 1634-1640
  • 172 Janis L, Kaplansky DB, DeCarbo WT. Early clinical experience with a fresh talar transplant inlay allograft for the treatment of osteochondral lesions of the talus. J Am Podiatr Med Assoc 2010; 100: 25-34
  • 173 Elias I, Raikin SM, Schweitzer ME et al. Osteochondral lesions of the distal tibial plafond: localization and morphologic characteristics with an anatomical grid. Foot Ankle Int 2009; 30: 524-529
  • 174 Bauer M, Johnsson K, Linden B. Osteochondritis dissecans of the ankle. J Bone Joint Surg Br 1987; 69: 93-96
  • 175 Angermann P, Jensen P. Osteochondritis dissecans of the talus: long-term results of surgical treatment. Foot Ankle 1989; 10: 161-163
  • 176 Hankemeier S, Müller EJ, Kaminski A et al. 10-Jahres-Ergebnisse knochenmarkstimulierender Therapie der Osteochondrosis dissecans tali. Unfallchirurg 2003; 106: 461-466