Klin Monbl Augenheilkd 2017; 234(02): 185-190
DOI: 10.1055/s-0042-124514
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Einfluss von Genussmitteln auf das Glaukom

Influence of Luxury Foodstuffs on Glaucoma
K. K. Huber-van der Velden
Augenklinik, Universitätsklinikum Düsseldorf
› Author Affiliations
Further Information

Publication History

eingereicht 14 November 2016

akzeptiert 14 December 2016

Publication Date:
31 January 2017 (online)

Zusammenfassung

Als Genussmittel werden Lebensmittel bezeichnet, die nicht wegen ihres Nährwerts und somit nicht zur Sättigung konsumiert werden. Klassische Genussmittel der Moderne sind Alkohol, koffeinhaltige Getränke, Kakao, Zucker und Tabak. Der folgende Übersichtsartikel möchte einige dieser modernen Genussmittel und ihren Einfluss auf das Glaukom im Einzelnen näher betrachten. So senkt Alkohol in kleinen Mengen den hohen Augendruck und hat einen positiven Einfluss auf die Durchblutung des Sehnervs. Darüber hinaus üben Rotweinpolyphenole vasoprotektive Effekte aus. Generell scheint Alkoholkonsum jedoch keinen signifikanten Einfluss auf die Prävalenz von Glaukom zu haben. Die wichtigste Quelle für Koffeinaufnahme ist der Kaffeekonsum. In einigen Studien bewirkte Kaffeekonsum keine Veränderungen des Augendrucks, während andere von einem Anstieg berichten. Eine große Studie konnte einen Zusammenhang zwischen starkem Kaffeeverbrauch und dem Risiko, an Pseudoexfoliationsglaukom zu erkranken, aufzeigen. Grüner und schwarzer Tee sind reiche Quellen von Flavonoiden mit antioxidativem Effekt. Zudem wurde ein leichter Trend zur Senkung des Augeninnendrucks gemessen. Bei Schokolade sollte man laut Studienlage die flavonoidreiche dunkle Schokolade mit antioxidativer Wirkung verzehren. Sie senkt den Blutdruck und verbessert die endothelabhängige Gefäßrelaxation. Ein Zuviel an Zuckerverzehr über viele Jahre kann bekanntlich zu einem erhöhten Body-Mass-Index (BMI) und einem Typ-2-Diabetes führen. Viele Studien zeigen einen positiven Zusammenhang zwischen BMI und Augendruck. Einige Studien haben signifikante Zusammenhänge zwischen Typ-2-Diabetes und Glaukomrisiko festgestellt. Rauchen, als weiteres sehr verbreitetes Genussmittel, verengt die Blutgefäße und mindert somit die Durchblutung des Sehnervs. Ansonsten ist die Studienlage bez. der Rolle des Rauchens als Risikofaktor für das Glaukom noch sehr uneinheitlich. Genussmittel können also Effekte auf das Glaukom haben, daher sollte bei Glaukompatienten zusätzlich nach dem Konsum diverser Genussmitteln in der Anamnese gefragt werden.

Abstract

The term “luxury foodstuffs” refers to foods which are not consumed because of their nutritional value. Classic modern luxury foodstuffs are alcohol, caffeine-containing drinks, cocoa, sugar and tobacco. The following review article examines some of these modern luxury foodstuffs in detail, as well as their influence on glaucoma. Thus, small quantities of alcohol lower high intraocular pressure and have a positive influence on the blood circulation of the optic nerve. In addition, red wine polyphenols exert vasoprotective effects. In general, however, alcohol consumption appears to have no significant effect on the prevalence of glaucoma. The most important source of caffeine intake is coffee consumption. In some studies, coffee consumption caused no changes in intraocular pressure, while others reported a rise. A large study showed a connection between heavy coffee consumption and the risk of pseudoexfoliation glaucoma. Green and black teas are rich sources of flavonoids with antioxidant activity. In addition, a slight trend for lowering the intraocular pressure has been measured. As regards chocolate, flavonoid-rich dark chocolate should be favoured, due to its antioxidant activity. It lowers blood pressure and improves endothelium-dependent vascular relaxation. Excessive sugar consumption over many years can lead to increased body mass index (BMI) and type 2 diabetes. Many studies show a positive relationship between BMI and intraocular pressure. Some studies have identified significant correlations between type 2 diabetes and the risk of glaucoma. Smoking is a very widespread stimulant; it narrows the blood vessels and thus reduces the blood circulation of the optic nerve. Otherwise, studies on the role of smoking as a risk factor for glaucoma have been very inconsistent. Luxury foodstuffs may effect glaucoma and should be included in the medical history.

 
  • Literatur

  • 1 Grimm J, Grimm W. Lemma genuszmittel. In: Grimm J, Grimm W. Hrsg. Deutsches Wörterbuch. München: DTV; 1984
  • 2 Hengartner T, Merki CM. Für eine Geschichte der Genussmittel. In: Hengartner T, Merki CM. Hrsg. Genussmittel. Ein kulturgeschichtliches Handbuch. Frankfurt: Campus; 1999: 11
  • 3 Hengartner T, Merki CM. Für eine Geschichte der Genussmittel. In: Hengartner T, Merki CM. Hrsg. Genussmittel. Ein kulturgeschichtliches Handbuch. Frankfurt: Campus; 1999: 13
  • 4 Mozaffarieh M, Grieshaber MC, Flammer J. Oxygen and blood flow: players in the pathogenesis of glaucoma. Mol Vis 2008; 14: 224-233
  • 5 Mozaffarieh M, Grieshaber MC, Orgül S. et al. The potential value of natural antioxidative treatment in glaucoma. Surv Ophthalmol 2008; 53: 479-505
  • 6 Kang JH, Willett WC, Rosner BA. et al. Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol 2007; 14: 141-147
  • 7 Giurlani BP, Obie LG, Petersen CG. et al. Alcohol and open angle glaucoma–influence on detection, IOP, BP/IOP ratios. J Am Optom Assoc 1978; 49: 409-416
  • 8 Wang S, Wang JJ, Wong TY. Alcohol and eye diseases. Surv Ophthalmol 2008; 53: 512-525
  • 9 Goldberg I, Clement CI. The water drinking test. Am J Ophthalmol 2010; 150: 447-449
  • 10 Weber A, Remky A, Bienert M. et al. Retrobulbar blood flow and visual field alterations after acute ethanol ingestion. Clin Ophthalmol 2013; 7: 1641-1646
  • 11 Xu L, You QS, Jonas JB. Prevalence of alcohol consumption and risk of ocular diseases in a general population: the Beijing Eye Study. Ophthalmology 2009; 116: 1872-1879
  • 12 Klein BE, Klein R, Ritter LL. Relationship of drinking alcohol and smoking to prevalence of open-angle glaucoma. The Beaver Dam Eye Study. Ophthalmology 1993; 100: 1609-1613
  • 13 Fan BJ, Leung YF, Wang N. et al. Genetic and environmental risk factors for primary open-angle glaucoma. Chin Med J 2004; 117: 706-710
  • 14 Mukamal KJ, Rimm EB. Alcoholʼs effects on the risk for coronary heart disease. Alcohol Res Health 2001; 25: 255-261
  • 15 Taylor B, Rehm J. Moderate alcohol consumption and diseases of the gastrointestinal system: A review of pathophysiological processes. Dig Dis 2005; 23: 177-180
  • 16 Coffee Statistics Report 2011. Im Internet: http://www.coffee-statistics.com/coffee_statistics_ebook.html Stand: 22.12.2016
  • 17 Massey LK. Caffeine and the elderly. Drugs Aging 1998; 13: 43-50
  • 18 Ozkan B, Yuksel N, Anik Y. et al. The effect of caffeine on retrobulbar hemodynamics. Curr Eye Res 2008; 33: 804-809
  • 19 Ricklefs G. Studies on the ways of life of glaucoma patients. Doc Ophthalmol 1968; 25: 43-99
  • 20 Ricklefs G, Pohls EU. Effect of caffeine containing tablets and Coca-Cola on the intraocular pressure of patients without glaucoma and patients with regulated glaucoma. Klin Monatsbl Augenheilkd 1969; 154: 546-551
  • 21 Okuno T, Sugiyama T, Tominaga M. et al. Effects of caffeine on microcirculation of the human ocular fundus. Jpn J Ophthalmol 2002; 46: 170-176
  • 22 Lofti K, Grunwald JE. The effect of caffeine on the human macular circulation. Invest Ophthalmol Vis Sci 1991; 32: 3028-3032
  • 23 Chandra P, Gaur A, Varma S. Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma. Clin Ophthalmol 2011; 5: 1623-1629
  • 24 Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002; 36: 992-995
  • 25 Higginbotham EJ, Kilimanjaro HA, Wilensky JT. et al. The effect of caffeine on intraocular pressure in glaucoma patients. Ophthalmology 1989; 96: 624-626
  • 26 Okimi PH, Sportsman S, Pickard MR. et al. Effects of caffeinated coffee on intraocular pressure. Appl Nurs Res 1991; 4: 72-76
  • 27 Ajayi OB, Ukwade MT. Caffeine and intraocular pressure in a Nigerian population. J Glaucoma 2001; 10: 25-31
  • 28 Graeber W. On the effect of caffeine on intraocular pressure in surgically or conservatively managed simple chronic glaucoma. Klin Monatsbl Augenheilkd 1968; 152: 357-365
  • 29 Makabe R. Uber die Reaktionsdifferenz von Normal-und Glaucomaugen and Provokationstest. Ophthalmologica 1970; 161: 460-465
  • 30 American Hospital Formulary Service. Drug information. Bethesda: American Society of Health System Pharmacists; 2006: 2431-2432
  • 31 Nurminen M-L, Niittynen L, Korpela R. et al. Coffee caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999; 53: 831-839
  • 32 Ajayi OB, Ukwade MT. Caffeine and intraocular pressure in a Nigerian population. J Glaucoma 2001; 10: 25-31
  • 33 Kurata K, Fujimoto H, Tsukuda R. et al. Aqueous humor dynamics in beagle dogs with caffeine-induced ocular hypertension. J Vet Med Sci 1998; 60: 737-739
  • 34 James JE. Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med 2004; 66: 63-71
  • 35 Haller CA. Caffeine. In: Olson KR. Poisoning and drug overdose. 5th ed.. New York: Lange Medical Books/McGraw-Hill; 2007: 142-143
  • 36 Fuller RW, Maxwell DL, Conradson T-BG. et al. Circulatory and respiratory effects of infused adenosine in conscious man. Br J Pharmacol 1987; 24: 309-317
  • 37 Smits P, Boekema P, De Abreu R. et al. Evidence for an antagonism between caffeine and adenosine in the human cardiovascular system. J Cardiovasc Pharmacol 1987; 10: 136-143
  • 38 Coney AM, Marshall JM. Role of adenosine and its receptors in the vasodilation induced in the cerebral cortex of the rat by systemic hypoxia. J Physiol 1998; 509: 507-518
  • 39 Hartley TR, Lovallo WR, Whitsett TL. et al. Caffeine and stress: implications for risk, assessment, and management of hypertension. J Clin Hypertens 2001; 3: 354-361
  • 40 Kurata K, Maeda M, Nishida E. et al. Relationship between caffeine induced ocular hypertension and ultrastructure changes of nonpigmented ciliary epithelial cells in rats. J Toxicol Sci 1997; 22: 447-454
  • 41 Jiwani AZ, Rhee DJ, Brauner SC. et al. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond) 2012; 26: 1122-1130
  • 42 Pasquale LR, Wiggs JL, Willett WC. et al. The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts. Invest Ophthalmol Vis Sci 2012; 53: 6427-6433
  • 43 Grubben MJ, Boers GH, Blom HJ. et al. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr 2000; 71: 480-484
  • 44 Urgert R, van Vliet T, Zock PL. et al. Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am J Clin Nutr 2000; 72: 1107-1110
  • 45 Christensen B, Mosdol A, Retterstol L. et al. Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol–a randomized controlled trial. Am J Clin Nutr 2001; 74: 302-307
  • 46 Leibovitch I, Kurtz S, Shemesh G. et al. Hyperhomocystinemia in pseudoexfoliation glaucoma. J Glaucoma 2003; 12: 36-39
  • 47 Vessani RM, Ritch R, Liebmann JM. et al. Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol 2003; 136: 41-46
  • 48 Puustjarvi T, Blomster H, Kontkanen M. et al. Plasma and aqueous humour levels of homocysteine in exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 2004; 242: 749-754
  • 49 Altintas O, Maral H, Yuksel N. et al. Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 2005; 243: 677-683
  • 50 Cumurcu T, Sahin S, Aydin E. Serum homocysteine, vitamin B 12 and folic acid levels in different types of glaucoma. BMC Ophthalmol 2006; 6: 6
  • 51 Tranchina L, Centofanti M, Oddone F. et al. Levels of plasma homocysteine in pseudoexfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol 2011; 249: 443-448
  • 52 Bleich S, Roedl J, von Ahsen N. et al. Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma. Am J Ophthalmol 2004; 138: 162-164
  • 53 Roedl JB, Bleich S, Reulbach U. et al. Homocysteine in tear fluid of patients with pseudoexfoliation glaucoma. J Glaucoma 2007; 16: 234-239
  • 54 Brooks AM, Gillies WE. The development of microneovascular changes in the iris in pseudoexfoliation of the lens capsule. Ophthalmology 1987; 94: 1090-1097
  • 55 Eagle jr. RC, Font RL, Fine BS. The basement membrane exfoliation syndrome. Arch Ophthalmol 1979; 97: 510-515
  • 56 Higginbotham EJ, Kilimanjaro HA, Wilensky JT. et al. The effect of caffeine on intraocular pressure in glaucoma patients. Ophthalmology 1989; 96: 624-626
  • 57 Kang JH, Willett WC, Rosner BA. et al. Pasquale LR. Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study. Invest Ophthalmol Vis Sci 2008; 49: 1924-1931
  • 58 Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 2006; 545: 51-64
  • 59 Wei H, Zhang X, Zhao JF. et al. Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas. Free Radic Biol Med 1999; 26: 1427-1435
  • 60 Terai N, Gedenk A, Spoerl E. et al. The short-term effect of flavonoid-rich dark chocolate on retinal vessel diameter in glaucoma patients and age-matched controls. Acta Ophthalmol 2014; 92: 341-345
  • 61 Hänsel R, Sticher O. Pharmakognosie. Phytopharmazie. 9. Aufl.. Heidelberg: Springer; 2009: 1098-1152
  • 62 Ogden CL, Yanovski SZ, Carroll MD. et al. The epidemiology of obesity. Gastroenterology 2007; 132: 2087-2102
  • 63 Yoshida M, Ishikawa M, Kokaze A. et al. Association of life-style with intraocular pressure in middle-aged and older Japanese residents. Jpn J Ophthalmol 2003; 47: 191-198
  • 64 Klein BE, Klein R, Linton KL. Intraocular pressure in an American community. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 1992; 33: 2224-2228
  • 65 Wu SY, Leske MC. Associations with intraocular pressure in the Barbados Eye Study. Arch Ophthalmol 1997; 115: 1572-1576
  • 66 Mori K, Ando F, Nomura H. et al. Relationship between intraocular pressure and obesity in Japan. Int J Epidemiol 2000; 29: 661-666
  • 67 Leske MC, Connell AM, Wu SY. et al. Risk factors for open-angle glaucoma. The Barbados Eye Study. Arch Ophthalmol 1995; 113: 918-924
  • 68 Gasser P, Stumpfig D, Schotzau A. et al. Body mass index in glaucoma. J Glaucoma 1999; 8: 8-11
  • 69 Pasquale LR, Kang JH, Manson JE. et al. Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women. Ophthalmology 2006; 113: 1081-1086
  • 70 Bonovas S, Peponis V, Filioussi K. Diabetes mellitus as a risk factor for primary open-angle glaucoma: a meta-analysis. Diabet Med 2004; 21: 609-614
  • 71 Chopra V, Varma R, Francis BA. et al. Type 2 diabetes mellitus and the risk of open-angle glaucoma: the Los Angeles Latino Eye Study. Ophthalmology 2008; 115: 227-232
  • 72 Ellis JD, Evans JM, Ruta DA. et al. Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma? DARTS/MEMO collaboration. Diabetes Audit and Research in Tayside Study. Medicines Monitoring Unit. Br J Ophthalmol 2000; 84: 1218-1224
  • 73 Gordon MO, Beiser JA, Kass MA. Ocular Hypertension Treatment Study Group. Is a History of Diabetes Mellitus Protective Against Developing Primary Open-angle Glaucoma?. Arch Ophthalmol 2008; 126: 280-281
  • 74 Tielsch JM, Katz J, Quigley HA. et al. Diabetes, intraocular pressure, and primary open-angle glaucoma in the Baltimore Eye Survey. Ophthalmology 1995; 102: 48-53
  • 75 de Voogd S, Ikram MK, Wolfs RCW. et al. Is diabetes mellitus a risk factor for open-angle glaucoma?: The Rotterdam Study. Ophthalmology 2006; 113: 1827-1831
  • 76 Leske MC, Suh-Yuh W, Anselm H. et al. Risk factors for incident open-angle glaucoma: The Barbados Eye Studies. Ophthalmology 2008; 115: 85-93
  • 77 Sato T, Roy S. Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells. Invest Ophthalmol Vis Sci 2002; 43: 170-175
  • 78 Johnson MA, Lutty GA, McLeod DS. et al. Ocular structure and function in an aged monkey with spontaneous diabetes mellitus. Exp Eye Res 2005; 80: 37-42
  • 79 Wilson MR, Martone J. Epidemiology of chronic open angle glaucoma. In: Ritch R, Shields MB, Krupin T. The Glaucomas. St. Louis: Mosby; 1996: 753-768
  • 80 World Health Organization. WHO report on the global tobacco epidemic, 2011. Warning about the dangers of tobacco. Geneva: World Health Organization; 2011
  • 81 Wilson MR, Hertzmark E, Walker AM. et al. A case-control study of risk factors in open angle glaucoma. Arch Ophthalmol 1987; 105: 1066-1071
  • 82 Bonovas S, Filioussi K, Tsantes A. et al. Epidemiological association between cigarette smoking and primary open-angle glaucoma: a meta-analysis. Public Health 2004; 118: 256-261
  • 83 Wise LA, Rosenberg L, Radin RG. et al. A prospective study of diabetes, lifestyle factors, and glaucoma among African-American women. Ann Epidemiol 2011; 21: 430-439
  • 84 Morgan RW, Drance SM. Chronic open-angle glaucoma and ocular hypertension: an epidemiological study. Br J Ophthalmol 1975; 59: 211-215
  • 85 Lee AJ, Rochtchina E, Wang JJ. et al. Does smoking affect intraocular pressure? Findings from the Blue Mountains eye study. J Glaucoma 2003; 12: 209-212
  • 86 Kang JH, Pasquale LR, Rosner BA. et al. Prospective study of cigarette smoking and the risk of primary open-angle glaucoma. Arch Ophthalmol 2003; 121: 1762-1768
  • 87 Edwards R, Thornton J, Ajit R. et al. Cigarette smoking and primary open angle glaucoma: a systematic review. J Glaucoma 2008; 17: 558-566
  • 88 Weih LM, Mukesh BN, McCarty CA. et al. Association of demographic, familial, medical, and ocular factors with intraocular pressure. Arch Ophthalmol 2001; 119: 875-880
  • 89 Tamaki Y, Araie M, Nagahara M. et al. Acute effects of cigarette smoking on tissue circulation in human optic nerve head and choroid-retina. Ophthalmology 1999; 106: 564-569
  • 90 Steigerwalt Jr RD, Laurora G, Incandela L. et al. Ocular and orbital blood flow in cigarette smokers. Retina 2000; 20: 394-397
  • 91 Timothy CO, Nneli RO. The effects of cigarette smoking on intraocular pressure and arterial blood pressure of normotensive young Nigerian male adults. Niger J Physiol Sci 2007; 22: 33-36