The Effect of Vitamin D Levels in Multisystem Inflammatory Syndrome in Children

Ahmet Kan; Mehmet Türe; Alper Akın; Kamil Yılmaz; Mehmet Sürücü; Edip Ünal; Velat Şen; Veysiye Hülya Üzel

doi:10.1055/s-0042-1749372

Journal of Pediatric Infectious Diseases, Table of Contents

J Pediatr Infect Dis 2022; 17(04): 194-199
DOI: 10.1055/s-0042-1749372

Original Article

The Effect of Vitamin D Levels in Multisystem Inflammatory Syndrome in Children

Authors

Ahmet Kan

¹Department of Pediatric Allergy and Immunology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Mehmet Türe

²Department of Pediatric Cardiology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Alper Akın

²Department of Pediatric Cardiology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Kamil Yılmaz

³Department of Pediatrics, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Mehmet Sürücü

³Department of Pediatrics, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Edip Ünal

⁴Department of Pediatric Endocrinology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Velat Şen

⁵Department of Pediatric Pulmonology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Veysiye Hülya Üzel

⁶Department of Pediatric Hematology, Dicle University Faculty of Medicine, Dicle University, Diyarbakır, Turkey

Abstract

Objective Multiple factors being overweight, asthmatic, or being of Asian or black ethnic origins have been reported vis-à-vis the “multisystem inflammatory syndrome in children” (MIS-C). There is an association between these conditions and vitamin D deficiency, which explains why MIS-C is more common in these patients. In the present study, we attempted to retrospective evaluate the 25-hydroxy vitamin D levels of patients with MIS-C, its association with acute phase reactants, its treatment, and clinical status.

Methods Patients aged between 1.5 months to 18 years with MIS-C were included in the study. All of the laboratory parameters, treatment, and response to the treatment were evaluated retrospectively. Two groups were formed. Patients had 25‐hydroxycholecalciferol D vitamin < 20 ng/mL in group 1 and ≥ 20 ng/mL in group 2.

Results A total of 52 patients were included in the study. There was no statistical difference between groups in terms of acceptance of the intensive care unit treatment (p = 0.29) and response to the first-line treatment (p = 0.56). A lower median lymphocyte count (p = 0.01) and a higher median C-reactive protein (p = 0.04) and procalcitonin (p = 0.01) with N-terminal pro-B-type natriuretic peptide (p = 0.025) values were found in group 1.

Conclusion Vitamin D deficiency was associated with an increased inflammatory response in children with MIS-C. More studies are required to determine the potential impact of vitamin D deficiency on the clinical outcome of MIS-C.

Keywords

multisystem inflammatory syndrome - vitamin D - inflammation parameters

Full Text

References

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