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Synfacts 2023; 19(11): 1097
DOI: 10.1055/s-0042-1752257
DOI: 10.1055/s-0042-1752257
Metals in Synthesis
Making Acyl Fluorides by Synergistic Palladium/Phosphine-Catalyzed Fluorocarbonylation
Zhao M,
Chen M,
Wang T,
Yang S,
Peng Q,
*,
Tang P.
*
Nankai University, Tianjin, P. R. of China
Fluorocarbonylation Via Palladium/Phosphine Synergistic Catalysis.
Nat. Commun. 2023;
14: 4583
DOI: 10.1038/s41467-023-40180-6
Fluorocarbonylation Via Palladium/Phosphine Synergistic Catalysis.
Nat. Commun. 2023;
14: 4583
DOI: 10.1038/s41467-023-40180-6
Key words
acyl fluorides - fluorocarbonylation - palladium catalysis - phosphine catalysis - synergistic catalysis
Significance
A novel method for the synthesis of acyl fluorides from potassium (het)aryl/alkyl trifluoroborates is reported. The trifluoromethyl arylsulfonate (TFMS) serves as source of the in situ generated hazardous COF2 gas.
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Comment
Detailed mechanistic studies including DFT calculations support the proposed mechanism. The dual role of the phosphine is noteworthy, acting as both organocatalyst and ligand of the palladium redox cycle.
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Publikationsverlauf
Artikel online veröffentlicht:
14. Oktober 2023
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