Piñeiro-Suárez M,
Álvarez-Constantino AM,
Fañanás-Mastral M.
*
Universidade de Santiago de Compostela, Spain
Copper-Catalyzed Enantioselective Borylative Allyl–Allyl Coupling of Allenes and Allylic
gem-Dichlorides.
ACS Catal. 2023;
13: 5578-5583
DOI:
10.1021/acscatal.3c00536
Key words
copper catalysis - allyboration - asymmetric catalysis - allenes
Significance
The group of Fañanás-Mastral reports a highly chemo-, regio-, enantio- and diasteroselective
copper-catalyzed synthesis of multifunctional internal 1,5-dienes. This reaction has
a large functional group tolerance and the products could be easily transformed into
more complex structure for example using coupling reactions.
Comment
The authors explain the high level of enantio- and diasteroselectivity observed in
this transformation by non-convalent substrate–ligand interactions. This result is
supported by DFT calculations.
