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Synfacts 2023; 19(09): 0881
DOI: 10.1055/s-0042-1752878
DOI: 10.1055/s-0042-1752878
Metals in Synthesis
Making Acid Chlorides from Olefins by Palladium-Catalyzed Regiodivergent Hydrochlorocarbonylation
Wu F,
Wang B,
Li N.-Q,
Yang H.-Y,
Ren Z.-H,
Guan Z.-H.
*
Northwest University, Xi’an, P. R. of China
Palladium-Catalyzed Regiodivergent Hydrochlorocarbonylation of Alkenes for Formation of Acid Chlorides.
Nat. Commun. 2023;
14: 3167
DOI: 10.1038/s41467-023-38748-3
Palladium-Catalyzed Regiodivergent Hydrochlorocarbonylation of Alkenes for Formation of Acid Chlorides.
Nat. Commun. 2023;
14: 3167
DOI: 10.1038/s41467-023-38748-3
Significance
Guan and co-workers disclosed a palladium-catalyzed hydrochlorocarbonylation of olefins to the corresponding acid chlorides. Depending on the choice of solvent and ligand, either branched or linear regioisomers are formed.
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Comment
The combination of acetic acid and a chlorosilane functions as a mild HCl source, thereby avoiding hydrochlorination as undesirable side reaction. Control experiments support the shown mechanism.
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Publikationsverlauf
Artikel online veröffentlicht:
16. August 2023
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