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Digestive Disease Interventions 2023; 07(01): 030-036
DOI: 10.1055/s-0042-1760371
Review Article

Neoadjuvant Treatment for Rectal Cancer and Nonoperative Management/Total Neoadjuvant Therapy

Amy Edwards-Murphy
1   Department of Academic Surgery, University Hospital Waterford, Waterford, Ireland
2   Department of Academic Surgery, University College Cork, Cork, Ireland
,
Peter Neary
1   Department of Academic Surgery, University Hospital Waterford, Waterford, Ireland
2   Department of Academic Surgery, University College Cork, Cork, Ireland
› Author Affiliations Funding No funding or grant was received for this study.
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Abstract

Treatment of locally advanced rectal cancer remains one of the most challenging in colorectal surgery. It has had an evolving landscape over the past three decades. This review describes the introduction of total neoadjuvant therapy—a term aimed to describe an approach where both systemic chemotherapy and chemoradiation are administered in the preoperative setting. This novel strategy has come to the fore with the strength of well-documented results of recent trials. Its implementation has begun globally, but long-term outcomes and data analysis to identify optimal schedules are eagerly awaited.

Keywords

total neoadjuvant therapy - rectal cancer - total mesorectal excision


Publication History

Received: 20 September 2022

Accepted: 05 December 2022

Article published online:
02 February 2023

© 2023. Thieme. All rights reserved.

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