Practically Simple Method for the Synthesis of N-Formyl Amino Acid Esters

Hisashi Yamamoto; Isai Ramakrishna

doi:10.1055/s-0043-1774914

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Synfacts 2024; 20(08): 0891
DOI: 10.1055/s-0043-1774914

Peptide Chemistry

Practically Simple Method for the Synthesis of N-Formyl Amino Acid Esters

Contributor(s):

Hisashi Yamamoto

,

Isai Ramakrishna

Chancellor T, *, Morton C. Hoffmann-La Roche, Nutley, USA
A Facile Procedure for the Synthesis of N-Formyl Amino Acid Esters.

Synthesis 1994; 1010-1023
DOI: 10.1055/s-1994-25628

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Abstract
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Key words

formylation - trimethyl orthoformate - triethyl orthoformate - N-formyl amino acid ester

Significance

Protecting groups play an inherent role in peptide chemistry. In 1994, the authors developed a facile procedure for synthesizing N-formyl amino acid esters using commercially available trimethyl orthoformate or triethyl orthoformate.

Comment

A series of N-formyl amino acid esters were synthesized in good yields with excellent optical purity. This method is practically simple and proceeds without racemization.

Publication History

Article published online:
25 July 2024

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

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