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Synfacts 2024; 20(09): 0995
DOI: 10.1055/s-0043-1774974
DOI: 10.1055/s-0043-1774974
Peptide Chemistry
N-Methylated Peptide Synthesis Using Flow Chemistry
Authors
Chen T.-H,
Ando A,
Shamato O,
Fuse S.
*
Nagoya University, Japan
Effect of Brønsted Acids on the Activation of Mixed Anhydride/Mixed Carbonic Anhydride and C-Terminal-Free N-Methylated Peptide Synthesis in a Micro-Flow Reactor.
Chem. Eur. J. 2024;
30: e202401402
DOI: 10.1002/chem.202401402
Effect of Brønsted Acids on the Activation of Mixed Anhydride/Mixed Carbonic Anhydride and C-Terminal-Free N-Methylated Peptide Synthesis in a Micro-Flow Reactor.
Chem. Eur. J. 2024;
30: e202401402
DOI: 10.1002/chem.202401402
Key words
N-methylated peptides - flow chemistry - epimerization - Brønsted acids - mixed anhydrides
Significance
N-Methylated peptides are important in organic synthesis. The authors disclosed a method for synthesizing C-terminus-free N-methylated peptides in a micro-flow reactor. Unexpected C-terminal epimerization of the peptides was also observed.
Comment
The authors investigated the effect of Brønsted acids towards the activation of mixed carbonic anhydride using flow chemistry for the synthesis of C-terminus-free N-methylated peptides which is limited up to dipeptides.
Publication History
Article published online:
16 August 2024
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