Buendía M,
Fernández-García JM,
Perles J,
Filippone S,
*,
Martín N.
*
Universidad Complutense de Madrid, Spain
Enantioselective Synthesis of a Two-Fold Inherently Chiral Molecular Nanographene.
Nat. Synth. 2024;
3: 545-553
DOI:
10.1038/s44160-024-00484-x
Key words
chiral nanographenes - chiral center - axial chirality - helicity
Significance
Enantioselective syntheses of a pair of all-carbon nanographene molecules, featuring
central, axial, and helical, three types of chiral elements, are achieved.
Comment
The key step is the enantioselective double substitution of two OH groups at the chiral
benzylic carbons by the aromatic nucleophiles. The resultant asymmetric stereo-configuration
biases the helical chirality subsequently appearing in the Scholl reaction.
