Synlett 2003(12): 1841-1843  
DOI: 10.1055/s-2003-41408
LETTER
© Georg Thieme Verlag Stuttgart · New York

Highly Convenient, One-Pot Synthesis of Nitriles from Aldehydes Using the NH2OH·HCl/NaI/MeCN System

Roberto Ballini*, Dennis Fiorini, Alessandro Palmieri
Dipartimento di Scienze Chimiche, Università di Camerino, Via S.Agostino 1 - 62032 Camerino-Italy
Fax: +39(073)7402297; e-Mail: roberto.ballini@unicam.it;
Further Information

Publication History

Received 25 July 2003
Publication Date:
28 August 2003 (online)

Abstract

Direct transformation of both aliphatic and aromatic aldehydes to the corresponding nitriles, can be easily performed by the reaction of an aldehyde with a slight excess of hydroxylamine hydrochloride, in refluxing acetonitrile and in the presence of 0.5 equivalents of sodium iodide as catalyst.