Lymphocyte Subpopulations in Bronchopulmonary Dysplasia

Praveen Ballabh; Maciej Simm; Jaishree Kumari; Alfred N. Krauss; Ajey Jain; Peter A. M. Auld; Susanna Cunningham-Rundles

doi:10.1055/s-2003-45387

American Journal of Perinatology, Table of Contents

Am J Perinatol 2003; 20(8): 465-476
DOI: 10.1055/s-2003-45387

ORIGINAL ARTICLE

Lymphocyte Subpopulations in Bronchopulmonary Dysplasia

Praveen Ballabh¹ , Maciej Simm² , Jaishree Kumari² , Alfred N. Krauss³ , Ajey Jain³ , Peter A.M. Auld³ , Susanna Cunningham-Rundles⁴

¹Division of Newborn Unit, Westchester Medical Center, Valhalla, New York
²The New York Presbyterian Cornell Medical Center
³Department of Pediatrics, Weill Medical College of Cornell University, New York, New York
⁴Cellular Immunology Laboratory, Weill Medical College of Cornell University, New York, New York

Abstract

ABSTRACT

A key role for inflammation in the etiology of bronchopulmonary dysplasia (BPD) has been proposed. In the present study we have evaluated lymphocyte subpopulations in 39 premature infants with respiratory distress syndrome (RDS) who did or did not develop BPD. The absolute number of lymphocytes was lower among infants with RDS who developed BPD compared with those who did not over the first two weeks of life (p < 0.020) as were percentage and absolute number of CD4⁺ T cells. By contrast, the proportions of CD3⁺CD8⁺ lymphocyte cells were not statistically different between non-BPD and BPD infants. B cell percentage was significantly decreased in BPD infants only on day 7. NK “bright” cells (CD56⁺) were highly enriched in all RDS groups. Interestingly, the percentage of CD4⁺ T cells expressing CD62L was selectively reduced in BPD infants. As a whole these data suggest that reduction of CD4⁺ T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD.

KEYWORDS

Bronchopulmonary dysplasia - lymphocyte subsets - L-selectin

Full Text

References

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