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Synfacts 2005(1): 0129-0129
DOI: 10.1055/s-2005-916020
DOI: 10.1055/s-2005-916020
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Furans by the Pd-Catalyzed Oshima-Utimoto Reaction
M. A. Evans, J. P. Morken*
The University of North Carolina, USA
Further Information
Publication History
Publication Date:
21 September 2005 (online)
Significance
A wide range of substrates with various olefin geometries and size of the R and R1 groups were tested and all gave high diastereoselectivity. PMB- and TBS-protected remote alcohols were compatible for these reaction conditions. The use of chiral starting material (as shown in the second paper) yielded good selectivity, making this a valuable synthetic tool for synthesis of these furans.