Synthesis of Interiotherin A and Gomisin R

doi:10.1055/s-2005-916043

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Synfacts 2005(2): 0187-0187
DOI: 10.1055/s-2005-916043

Synthesis of Natural Products and Potential Drugs

Synthesis of Interiotherin A and Gomisin R

Contributor(s): Philip Kocienski, Fiona Black
R. S. Coleman*, S. R. Gurrala
The Ohio State University, Columbus, USA

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Publication History

Publication Date:
25 October 2005 (online)

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Significance

Many dibenzocyclooctadiene lignans have been isolated from the Schisandraceae family of plants and several of these show interesting biological activities. Interiotherin A, isolated from the vine Kadsura interior, inhibits the replication of HIV. Angeloylgomisin R is a closely related analogue of Interiotherin A.