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Synfacts 2005(2): 0205-0205  
DOI: 10.1055/s-2005-916065
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Carbonylative Sonogashira Synthesis of Quinolines and Naphthyridines

Contributor(s): Victor Snieckus, Farhad Nowrouzi
G. Abbiati, A. Arcadi, V. Canevari, L. Capezzuto, E. Rossi*
Universita Degli Studi di Milano, And Universita de L’Aquila, Copito, Italy
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Publication History

Publication Date:
25 October 2005 (online)

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Significance

A palladium-mediated multicomponent domino reaction leading to 2-aryl-4-amino-quinolines and 2-aryl-4-amino[1,8]naphthyridines starting from 2-ethynylarylamines, aryl iodides, primary amines and carbon monoxide in a one-pot procedure is reported.

Varieties of primary amines which have different functional groups and electron-rich or electron-deficient aryl iodide have been used to provide products in modest to good yields (42-99%).