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Synfacts 2005(2): 0223-0223
DOI: 10.1055/s-2005-916075
DOI: 10.1055/s-2005-916075
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Catalytic Enantioselective Enolate Alkylations with Orthoesters
D. A. Evans*, R. J. Thomson
Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
25 October 2005 (online)
Significance
Catalytic enantioselective methods for enolate alkylations have not been widely explored as of yet. This communication demonstrates an effective method for introducing an acetal functionality with high enantioselectivity. A wide variety of α-substituents are tolerated, with no detrimental effect towards enantioselectivity.