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Synfacts 2005(2): 0244-0244  
DOI: 10.1055/s-2005-916119
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Alkyl-Alkyl Negishi Cross-Coupling Utilizing a Pd-NHC Catalyst

Contributor(s): Paul Knochel, Andrei Gavryushin
N. Hadei, E. A. B. Kantchev, C. O’Brien, M. G. Organ*
York University, Toronto, Canada
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Publication History

Publication Date:
25 October 2005 (online)

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Significance

This work is the first example of Pd-catalyzed sp3-sp3 cross-coupling reaction in the presence of N-heterocyclic carbenes as ligands. The process is performed at room temperature and highly tolerant to functional groups like ester, nitrile and phthalimide.