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Synfacts 2006(1): 0007-0007  
DOI: 10.1055/s-2005-921654
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Allocyathin

Contributor(s): Philip Kocienski, John Cooksey
B. M. Trost*, L. Dong, G. M. Schroeder
Stanford University, USA
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

(+)-Allocyathin is isolated from the fruit bodies of Cyathus earlei. It has antibacterial and antifungal properties. The challenge in the synthesis of Allocyathin is the construction of the characteristic angularly fused 5-6-7 tricyclic skeleton, containing a conjugated trienal motif and 1,4-anti stereocenters at each ring junction.