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Synfacts 2006(1): 0008-0008  
DOI: 10.1055/s-2005-921657
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Coleophomone B

Contributor(s): Philip Kocienski, John Cooksey
K. C. Nicolaou*, T. Montagnon, G. Vassilikogiannakis, C. J. N. Mathison
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

Coleophomones B, C and D are isolated from the fungal broths Strachybotrys cylindrospora, Strachybotrys parvispora Hughes and Coleophoma sp. They exhibit anti-bacterial activity via inhibition of a transglycosylase enzyme.