PDF icon PDF herunterladen
Synfacts 2006(1): 0052-0052  
DOI: 10.1055/s-2005-921673
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

(S,S,S)-REMB-Catalyzed Enantioselective Aza-Michael Reactions

Contributor(s): Mark Lautens, Andrew Martins
N. Yamagiwa, H. Qin, S. Matsunaga*, M. Shibasaki*
University of Tokyo, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
16. Dezember 2005 (online)

   Lizenzen und Reprints
Preview

Significance

The aza-Michael reaction remains as one of the premier ways to synthesize β-amino carbonyl compounds. Using a heterobimetallic catalyst, a wide variety of aromatic Michael acceptors can be converted enantioselectively into β-amines with excellent yields and enantioselectivities.