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Synfacts 2006(1): 0081-0081  
DOI: 10.1055/s-2005-921706
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Polymeric 1,3-Dithiane Reagents

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Takayasu Arakawa
V. Bertini*, F. Lucchesini, M. Pocci, S. Alfei
Università di Genova, Italy
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

An odorless synthesis of aldehydes 5 from a thioacetal 2 and a Merrifield resin 1 was demonstrated. Thus, polymeric 1,3-dithiane reagent 3 was prepared from chloromethylated polystyrene 1 with thioacetal 2 in 97-98%. An alkylation followed by removal of the polymer supports afforded 5 in moderate yields.